Increased Penicillin Nonsusceptibility of Nonvaccine-Serotype Invasive Pneumococci Other than Serotypes 19A and 6A in Post-7-Valent Conjugate Vaccine Era
Increased Penicillin Nonsusceptibility of Nonvaccine-Serotype Invasive Pneumococci Other than Serotypes 19A and 6A in Post-7-Valent Conjugate Vaccine Era
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DOI：
10.1086/650496
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发表时间：
2010-03-01
影响因子：
6.4
通讯作者：
Beall, Bernard W.
中科院分区：
文献类型：
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作者：
Gertz, Robert E.;Li, Zhongya;Beall, Bernard W.
根据 2007 年美国基于人群的侵袭性肺炎球菌监测，3,511 株分离株中的 898 株（26%）对青霉素不敏感。 19A 以外的非七价肺炎球菌结合疫苗 (PCV7) 血清型占这些青霉素不敏感分离株的 40%；其中，血清型 15A (11%)、23A (8%)、35B (8%) 和 6C (5%) 最常见（总共占青霉素不敏感分离株的 32%）。除 6C 外，每个都代表早于 PCV7 引入的单一血清型和克隆复合体组合。我们评估了非 PCV7 血清型的遗传特征和对青霉素的不敏感性，发现血清型 15A、23A、35B 和 6C 中特定青霉素不敏感克隆的比例增加，这可能表明这些个体血清型内群体结构的基本变化。
According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of these, serotypes 15A (11%), 23A (8%), 35B (8%), and 6C (5%) were most common (cumulatively 32% of penicillin-nonsusceptible isolates). Each except 6C represented a single serotype and clonal complex combination that predated the introduction of PCV7. We evaluated the genetic characteristics and nonsusceptibility to penicillin of non-PCV7 serotypes, and we found increased proportions of specific penicillin-nonsusceptible clones in serotypes 15A, 23A, 35B, and 6C, which potentially indicates a basic change of population structure within these individual serotypes.