Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen.
Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen.
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妊娠疱疹自身抗体可识别 180 kD 人类表皮抗原。
DOI：
10.1172/jci113554
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Anhalt,GJ
中科院分区：
文献类型：
--
作者：
Morrison,LH;Labib,RS;Zone,JJ;Diaz,LA;Anhalt,GJ
妊娠疱疹是一种妊娠期自身免疫性大疱性皮肤病，与大疱性类天疱疮（BP）有许多共同的发现，后者是一种老年疾病。本研究首次鉴定了HG自身抗体所识别的抗原，并与BP自身抗体所识别的抗原进行了比较。从16 HG和17 BP患者，并从正常孕妇的血清进行了评价免疫荧光（IF）的研究和免疫印迹对人表皮提取物。89%的HG血清循环抗体的IF识别一个180 kD的蛋白免疫印迹。71%的BP血清识别240 kD的条带，但47%的血清检测到180 kD的蛋白与HG血清检测到的抗原共迁移。对照血清均未识别任何特异性条带。这些发现表明，180 kD表皮蛋白可能是HG因子检测到的抗原，它们也定义了HG和BP之间的免疫相似性。
Herpes gestationis (HG) is a putative autoimmune bullous dermatosis of pregnancy which shares many findings with bullous pemphigoid (BP), a disease of the elderly. This study identifies for the first time the antigen detected by HG autoantibodies and compares it with that recognized by BP autoantibodies. Sera from 16 HG and 17 BP patients, and from normal pregnant women were evaluated by immunofluorescent (IF) studies and immunoblotted against human epidermal extracts. 89% of HG sera with circulating antibodies by IF recognized a 180-kD protein by immunoblotting. 71% of BP sera recognized a 240-kD band, but 47% detected a 180-kD protein that comigrated with the antigen detected by HG sera. None of the control sera recognized any specific bands. These findings suggest that the 180-kD epidermal protein may be the antigen detected by the HG factor and they also define immunologic similarities between HG and BP.Images