Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: Comparison with aminoguanidine
Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: Comparison with aminoguanidine
复制标题
DOI：
10.1006/bbrc.1996.0366
复制
发表时间：
1996-03-07
影响因子：
3.1
通讯作者：
Hudson, BG
中科院分区：
文献类型：
--
作者：
Booth, AA;Khalifah, RG;Hudson, BG
葡萄糖对蛋白质的非酶糖基化导致毒性和免疫原性晚期糖基化终产物（AGEs）的形成，可能是糖尿病、衰老以及可能的神经退行性疾病（如阿尔茨海默氏症）的病理表现的主要原因。我们测试了各种维生素B-1和B-6衍生物对牛血清白蛋白、核糖核酸酶A和人血红蛋白抗原AGE形成的体外抑制作用。在这些抑制剂中，吡哆胺和焦磷酸硫胺素能有效抑制AGE的形成，并且比氨基胍更有效，这表明这两种化合物可能在预防糖尿病血管并发症方面具有新的治疗潜力。一个意想不到的发现是氨基胍抑制糖基化的后期动力学阶段比早期阶段弱得多。(C) 1996学术出版社，Inc.
Nonenzymatic glycation of proteins by glucose leading to the formation of toxic and immunogenic advanced glycation end products (AGEs) may be a major contributor to the pathological manifestations of diabetes mellitus, aging, and, possibly, neurodegenerative diseases such as Alzheimer's. We tested the in vitro inhibition of antigenic AGE formation on bovine serum albumin, ribonuclease A, and human hemoglobin by various vitamin B-1 and B-6 derivatives. Among the inhibitors, pyridoxamine and thiamine pyrophosphate potently inhibited AGE formation and were more effective than aminoguanidine, suggesting that these two compounds may have novel therapeutic potential in preventing vascular complications of diabetes. An unexpected finding was that aminoguanidine inhibited the late kinetic stages of glycation much more weakly than the early phase. (C) 1996 Academic Press, Inc.