Sex differences in concentrations of exhaled nitric oxide and plasma nitrate
Sex differences in concentrations of exhaled nitric oxide and plasma nitrate
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DOI：
10.1016/0024-3205(95)02311-9
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发表时间：
1996-01-05
期刊：
影响因子：
6.1
通讯作者：
Eichler, HG
中科院分区：
文献类型：
--
作者：
Jilma, B;Kastner, J;Eichler, HG
一氧化氮（NO）通常被认为是一种内源性血管保护剂。各种研究表明，女性性激素雌二醇，有助于众所周知的心血管疾病的性别差异，可能会增加NO的产生，因此，我们研究了NO的产生的性别差异，通过测量单次呼吸NO呼气和血浆硝酸盐（NO3）水平，NO的稳定终代谢产物。在这项观察性试验中，22名男性和21名女性志愿者，19至38岁，每周研究3天。NO的中位浓度在女性中为十亿分之20（95% CI：16至32 ppb），在男性中为34 ppb（95% CI：31至58 ppb）。NO3的中位血浆浓度在女性中为14 μ M/L（95% CI：11至23 μ M/L），在男性中为27 μ M/L（95% CI：24至37 μ M/L）。因此，男性呼出的NO比男性多59%（p
Nitric oxide (NO) is generally considered as an endogenous vasoprotective agent. Various studies indicate that the female sex hormone estradiol, that contributes to the well known gender differences in cardiovascular disease, may enhance NO-production, Thus we studied sex differences in NO-generation by measuring single breath NO-exhalation and plasma levels of nitrate (NO3), the stable endmetabolite of NO. In this observational trial 22 male and 21 female volunteers, 19 to 38 years of age, were studied on 3 days at weekly intervals. Median concentrations of NO were 20 parts per billion (95% CI: 16 to 32 ppb) in women and 34 ppb (95% CI 31 to 58 ppb) in men. The median plasma concentrations of NO3 were 14 mu M/L (95% CI: 11 to 23 mu M/L) in women and 27 mu M/L (95% CI: 24 to 37 mu M/L) in men. Thus, men exhaled 59% more NO (p