Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray
Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray
复制标题
可切换探针：通过印迹微阵列筛选 pH 触发和 VEGFR2 靶向肽。
DOI：
10.1039/c6cc01302c
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Hu, Zhiyuan
中科院分区：
文献类型：
--
作者：
Qian, Yixia;Wang, Weizhi;Hu, Zhiyuan
一个可切换的亲和肽，STP，从一个高通量文库筛选出集成印迹微阵列。STP是pH触发的，也是标记物VEGFR2的配体。只有在VEGFR2过表达和温和的酸性环境下，才能“开启”和加速高效的细胞识别和穿透以及体内图像。
One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.