The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells
The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells
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癌蛋白HBXIP通过激活转录因子E2F1上调Skp2促进乳腺癌细胞增殖
DOI：
10.1016/j.canlet.2013.01.029
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发表时间：
2013-06-01
期刊：
影响因子：
9.7
通讯作者：
Zhang, Xiaodong
中科院分区：
文献类型：
--
作者：
Xu, Fuqiang;You, Xiaona;Zhang, Xiaodong
乙肝X相互作用蛋白(HBXIP)是一种新的癌蛋白。在本研究中，我们发现在临床乳腺癌组织和细胞系中，HBXIP的表达水平与S期蛋白相关蛋白2(Skp2)的表达水平呈正相关。此外，我们还发现HBXIP能够通过结合Skp2启动子中的-640/-443区域激活E2F转录因子1(E2F1)来激活Skp2启动子。Skp2在HBXIP促进乳腺癌细胞增殖的体内外过程中发挥重要作用。结论：HBXIP通过激活E2F1上调Skp2，促进乳腺癌细胞增殖。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. In this study, we found that the expression levels of HBXIP were positively associated with those of S-phase kinase-associated protein 2 (Skp2) in clinical breast cancer tissues and cell lines. Moreover, we found that HBXIP was able to stimulate the promoter of Skp2 through binding to the -640/-443 region in Skp2 promoter involving activating E2F transcription factor 1 (E2F1). Skp2 plays crucial roles in HBXIP-enhanced proliferation of breast cancer cells in vitro and in vivo. We conclude that HBXIP up-regulates Skp2 via activating E2F1 to promote proliferation of breast cancer cells. (C) 2013 Elsevier Ireland Ltd. All rights reserved.