Accuracy of Two-Dimensional Shear Wave Elastography and Attenuation Imaging for Evaluation of Patients With Nonalcoholic Steatohepatitis
Accuracy of Two-Dimensional Shear Wave Elastography and Attenuation Imaging for Evaluation of Patients With Nonalcoholic Steatohepatitis
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DOI：
10.1016/j.cgh.2020.05.034
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发表时间：
2021-03-18
影响因子：
12.6
通讯作者：
Choi, Byung Ihn
中科院分区：
文献类型：
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作者：
Lee, Dong Ho;Cho, Eun Ju;Choi, Byung Ihn
背景与目的：我们评估了使用衰减成像和二维剪切波弹性成像（2D-SWE）检测非酒精性脂肪性肝病（NAFLD）患者脂肪变性和纤维化的多参数方法的准确性。我们研究了102例肝酶水平升高或疑似NAFLD的患者，在活检收集和分析前立即进行衰减成像和2D-SWE检查（参考标准），2018年1月至2019年7月。我们收集了衰减成像的衰减系数（dB/cm/MHz）、肝脏硬度测量和2D-SWE的剪切波色散斜率（SWDS，[m/s]/kHz）数据。进行多元线性回归分析，以确定与每个参数相关的因素。结果：衰减系数与脂肪变性分级相关（P
BACKGROUND & AIMS: We evaluated the accuracy of a multiparametric approach using attenuation imaging and 2dimensional shear wave elastography (2D-SWE) for the detection of steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).METHODS: We studied 102 patients with increased levels of liver enzymes or suspicion of NAFLD, examined by attenuation imaging and 2D-SWE, immediately before biopsy collection and analysis (reference standard), from January 2018 to July 2019. We collected data on the attenuation coefficient (dB/cm/MHz) from attenuation imaging, liver stiffness measurements, and shear wave dispersion slope (SWDS, [m/s]/kHz) from 2D-SWE. Multivariate linear regression analysis was performed to identify factors associated with each parameter. Diagnostic performance was determined from area under the receiver operating curve (AUROC) values.RESULTS: The attenuation coefficient was associated with steatosis grade (P