CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY
CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY
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DOI：
10.1212/wnl.45.2.255
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发表时间：
1995-02-01
期刊：
影响因子：
9.9
通讯作者：
MILLER, DH
中科院分区：
文献类型：
--
作者：
FILIPPI, M;PATY, DW;MILLER, DH
我们对281例多发性硬化（MS）患者进行了两次常规非增强T2加权脑MRI扫描，间隔24至36个月。在每次扫描时，使用Kurtake扩展残疾状态量表（EDSS）对临床残疾进行评级。两次检查之间的残疾变化与新的（斯皮尔曼等级相关系数= 0.13; p = 0.02）和扩大的（斯皮尔曼等级相关系数= 0.18; p = 0.002）MRI病变数量相关性较弱，但显著。这一结果表明，在MS的确定性（III期）临床治疗试验中，脑T-2加权MRI是疾病活动的有用补充标志物。
We obtained two conventional unenhanced T-2-weighted brain MRI scans, separated by an interval of 24 to 36 months, in 281 patients with multiple sclerosis (MS). At the time of each scan, clinical disability was rated using the Kurtake Expanded Disability Status Scale (EDSS). Changes in disability between the two examinations correlated weakly but significantly with the number of new (Spearman's rank correlation coefficient = 0.13; p = 0.02) and enlarging (Spearman's rank correlation coefficient = 0.18; p = 0.002) MRI lesions. This result suggests that brain T-2-weighted MRI is a useful supplementary marker of disease activity in definitive (phase III) clinical treatment trials in MS.