Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission
Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission
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DOI：
10.1016/j.meegid.2012.01.017
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发表时间：
2012-03-01
影响因子：
3.2
通讯作者：
Zhuang, Hui
中科院分区：
文献类型：
--
作者：
Liu, Peng;Li, Lingjun;Zhuang, Hui
在中国看来，戊型肝炎是一个公共卫生问题。为了解中国地区戊型肝炎病毒(HEV)的总体分子流行病学，分析1986年至2011年中国地区人与猪之间的跨种传播情况，从GenBank中检索到626株HEV全序列和部分序列(本组鉴定的89株HEV株)，并进行系统发育分析。中国人群中有3种HEV亚型和11种亚型。此外，中国体内也普遍存在兔戊型肝炎病毒，其基因分型存在争议。基因1型是2000年以前分离最多的基因，主要分布在新疆、北京和中国东部。然而，近10年来在中国大部分地区发现的基因4在全国范围内的分离频率已超过基因1。仅在中国东部发现了3型HEV毒株，并被认为是从日本进口的。在人和猪中均发现了基因3和4，中国可能在东北、西北、华北、东部和南部发生了猪到人的跨种传播。这些结果表明，中国流行的HEV毒株具有相当大的遗传多样性，人畜共患传播在猪与人之间的传播普遍存在。(C)2012爱思唯尔B.V.保留所有权利。
Hepatitis E is considered as a public health problem in China. To determine the overall molecular epidemiology of hepatitis E virus (HEV) and analyze the situation of cross-species transmission between humans and swine in China over the last 25 years (1986-2011), 626 HEV complete and partial sequences (89 isolates identified by our group) isolated from humans and animals in China were retrieved from GenBank and subjected to phylogenetic analysis. There were three genotypes and 11 sub-genotypes of HEV prevailing in China. Furthermore, rabbit HEVs, of which the genotype is controversial, are also widespread in China. Genotype 1 was the most isolated genotype prior to 2000 and mainly detected in Xinjiang, Beijing and East China. However, genotype 4, which was identified in most regions of China during the last 10 years, has overtaken genotype 1 in frequency of isolation nationwide. Genotype 3 HEV strains have been found only in eastern China and were thought to be imported from Japan. Both genotypes 3 and 4 were found in humans and swine and cross-species transmission from pigs to humans of the two genotypes may have occurred in Northeast, Northwest, North, East and South China. These results indicate that HEV strains with considerable genetic diversity are widespread and the zoonotic transmission between swine and humans appears ubiquitous in China. (C) 2012 Elsevier B.V. All rights reserved.