TRANSLATIONAL CONTROL IN INFLUENZA VIRUS-INFECTED CELLS
TRANSLATIONAL CONTROL IN INFLUENZA VIRUS-INFECTED CELLS
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DOI：
10.1159/000468764
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
KRUG, RM
中科院分区：
文献类型：
--
作者：
KATZE, MG;KRUG, RM
A型流感病毒已被证明建立了一个翻译控制系统，使得在感染期间宿主细胞蛋白质合成受到显着抑制，并且病毒mRNA被选择性且有效地翻译。以下综述总结了流感为实现这些目标而采用的复杂策略。其中包括：（i）防止新产生的细胞mRNA进入感染细胞的细胞质;（ii）抑制预先存在的细胞mRNA的翻译的起始和延伸步骤;（iii）具有增强翻译的结构特征的RNA;（iv）下调干扰素诱导的蛋白激酶的编码机制，从而允许总蛋白合成水平保持高水平。
Influenza virus type A has been shown to establish a translational control system such that during infection there is a dramatic inhibition of host cell protein synthesis and viral mRNAs are selectively and efficiently translated. The following review summarizes the complex strategies employed by influenza to accomplish these goals. These include: (i) preventing newly made cellular mRNAs from entering the cytoplasm of infected cells; (ii) inhibiting the initiation and elongation steps of translation of preexisting cellular mRNAs; (iii) possessing RNAs with structural features which enhance translation; (iv) encoding mechanisms to downregulate the interferon induced protein kinase thus allowing overall protein synthesis levels to remain high.