Strength and resilience of developing brain circuits predict adolescent emotional and stress responses during the COVID-19 pandemic
Strength and resilience of developing brain circuits predict adolescent emotional and stress responses during the COVID-19 pandemic
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DOI：
10.1093/cercor/bhae164
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发表时间：
2024-04-26
期刊：
影响因子：
3.7
通讯作者：
Stamoulis，Catherine
中科院分区：
文献类型：
--
作者：
Hu，Linfeng;Stamoulis，Catherine
新冠肺炎大流行对年轻人产生了深远但尚未完全了解的不良影响。为了阐明大脑回路在青少年如何应对大流行的压力源中的作用，我们调查了他们的流行期前组织作为大流行前15个月心理/情绪健康的预测因子。我们分析了青少年大脑认知发展研究中2,641名青少年[中位年龄(四分位数范围) = 144.0(13.0)个月，女性47.7%]的休息状态网络，以及从2020年5月到2021年5月每2到3个月收集一次的心理健康、压力、悲伤和积极情绪的纵向评估。拓扑弹性和/或网络实力在多个时间点预测总体心理健康、压力和悲伤(但不是积极影响)，但主要是在2020年12月和2021年5月。在2020年12月，显著网络的较高弹性预示着较好的心理健康(β = 为0.19，95%CI = 为[0.06，0.31]，P= 0.01)。左侧凸起、奖赏、边缘和前额叶皮质以及丘脑、纹状体、杏仁核连接较低预示较高的压力(β = −为0.46至−为0.20，CI为 = [−为0.72，−为0.07，P<； 为0.03)。较低的双边健壮性(较高的脆弱性)和/或这些网络的连通性在2020年12月和2021年5月预示着较高的悲伤(β = −0.514至−0.19，CI = [−0.81，−0.05)，P<； 0.04。这些发现表明，在大流行期间，大脑回路的组织可能在青少年压力和心理/情绪健康方面发挥了关键作用。
The COVID-19 pandemic has had profound but incompletely understood adverse effects on youth. To elucidate the role of brain circuits in how adolescents responded to the pandemic’s stressors, we investigated their prepandemic organization as a predictor of mental/emotional health in the first ~15 months of the pandemic. We analyzed resting-state networks fromn= 2,641 adolescents [median age (interquartile range) = 144.0 (13.0) months, 47.7% females] in the Adolescent Brain Cognitive Development study, and longitudinal assessments of mental health, stress, sadness, and positive affect, collected every 2 to 3 months from May 2020 to May 2021. Topological resilience and/or network strength predicted overall mental health, stress and sadness (but not positive affect), at multiple time points, but primarily in December 2020 and May 2021. Higher resilience of the salience network predicted better mental health in December 2020 (β = 0.19, 95% CI = [0.06, 0.31],P= 0.01). Lower connectivity of left salience, reward, limbic, and prefrontal cortex and its thalamic, striatal, amygdala connections, predicted higher stress (β = −0.46 to −0.20, CI = [−0.72, −0.07],P< 0.03). Lower bilateral robustness (higher fragility) and/or connectivity of these networks predicted higher sadness in December 2020 and May 2021 (β = −0.514 to −0.19, CI = [−0.81, −0.05],P< 0.04). These findings suggest that the organization of brain circuits may have played a critical role in adolescent stress and mental/emotional health during the pandemic.