Interleukin-1 increases activity of the gastric vagal afferent nerve partly via stimulation of type A CCK receptor in anesthetized rats
Interleukin-1 increases activity of the gastric vagal afferent nerve partly via stimulation of type A CCK receptor in anesthetized rats
复制标题
DOI：
10.1016/s0165-1838(96)00111-7
复制
发表时间：
1997-01-12
期刊：
影响因子：
--
通讯作者：
Lundeberg, T
中科院分区：
文献类型：
--
作者：
Kurosawa, M;UvnasMoberg, K;Lundeberg, T
在戊巴比妥麻醉大鼠，观察胃迷走神经传入神经对静脉注射白细胞介素1 β（IL-1 β）的反应及胆囊收缩素（CCK）的参与。静脉给药2 μ g。kg（-1）的IL-1 β引起传入活动增加，给药后30 min达到对照活动的150%，并持续80 min以上。在A型CCK受体拮抗剂预处理的动物中，神经活动的增加显著减少。IL-1 β还显著增加全身血液中CCK浓度。此外，证实静脉内给予CCK通过A型CCK受体产生神经活动的增加。这些发现表明，全身应用IL-1 β增加了小肠粘膜内分泌细胞分泌的全身血液中的CCK浓度，而胃血流中的CCK又通过刺激胃中的A型CCK受体增强或部分参与了IL-1 β诱导的胃迷走神经传入神经的兴奋。一个可能的参与IL-1相关的兴奋的胃迷走神经传入神经IL-1诱导的厌食症进行了讨论。
The response of mass activity of the gastric vagal afferent nerve to intravenous administration of interleukin-1 beta (IL-1 beta) and the involvement of cholecystokinin (CCK) in the response were investigated in pentobarbital-anesthetized rats. Intravenous administration of 2 mu g . kg(-1) of IL-1 beta caused an increase in the afferent activity, which reached 150% of control activity by 30 min after administration and persisted for more than 80 min. The increase in the nerve activity was significantly reduced in animals pretreated with a type A CCK receptor antagonist. IL-1 beta also significantly increased the CCK concentration in systemic blood. Furthermore, it was confirmed that intravenous administration of CCK produced an increase in the nerve activity via the type A CCK receptor. These findings suggest that systemically applied IL-1 beta increases CCK concentration in systemic blood secreted from mucosal endocrine cells of the small intestine, and that in turn CCK in the gastric blood flow augments or partly participates in the IL-1 beta-induced excitation of the gastric vagal afferent nerve via stimulation of the type A CCK receptor in the stomach. A possible involvement of IL-1-related excitation of the gastric vagal afferent nerve in IL-1-induced anorexia is discussed.