Bioavailability of Quercetin: Problems and Promises
Bioavailability of Quercetin: Problems and Promises
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DOI：
10.2174/09298673113209990120
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发表时间：
2013-07-01
影响因子：
4.1
通讯作者：
Zhai, G.
中科院分区：
文献类型：
--
作者：
Cai, X.;Fang, Z.;Zhai, G.
槲皮素（Quercetin，QC）是一种典型的植物黄酮类化合物，具有抗炎、抗氧化、抗癌、抗过敏、抗衰老等多种药理作用。但由于其溶解性差、生物利用度低、渗透性差、不稳定等缺点，限制了其在药学领域的应用。为了提高QC的生物利用度，已经采取了许多方法，包括使用有前途的药物递送系统，如包合复合物、脂质体、纳米颗粒或胶束，这些系统似乎提供更高的溶解度和生物利用度。在不久的将来，QC生物利用度的提高可能会使该产品成为治疗人类疾病的治疗剂的最前沿。
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.