Mechanisms by which exercise improves bone strength
Mechanisms by which exercise improves bone strength
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DOI：
10.1007/bf03026318
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Robling, AG
中科院分区：
文献类型：
--
作者：
Turner, CH;Robling, AG
某些运动可以诱导成骨和提高骨强度，但骨力学传导所涉及的生物学过程才刚刚开始被理解。目前的研究中出现了几种途径，包括与膜离子通道相关的钙信号传导、三磷酸腺苷信号传导、第二信使（如胰高血糖素和一氧化氮）以及涉及丝裂原活化蛋白激酶的信号传导。最近才被研究的机械感测装置的一个特征是脱敏的重要作用。插入“休息”期以减少脱敏效应的实验方案可以使机械负荷的合成代谢反应加倍。减少脱敏的运动可以提供一种有效的方法来建立骨骼强度。
Certain exercises can induce osteogenesis and improve bone strength, yet the biological processes involved in bone mechanotransduction are only beginning to be understood. Several pathways are emerging from current research, including calcium signaling associated with membrane ion channels, adenosine triphosphate signaling, second messengers such as prostaglandins and nitric oxide, and signaling involving mitogen-activated protein kinase. One characteristic of the mechanosensing apparatus that has only recently been studied is the important role of desensitization. Experimental protocols that insert "rest" periods to reduce the effects of desensitization can double anabolic responses to mechanical loading. Exercises that reduce desensitization may provide an effective means to build bone strength.