Keratocyte and fibroblast phenotypes in the repairing cornea
Keratocyte and fibroblast phenotypes in the repairing cornea
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DOI：
10.1016/s1350-9462(98)00033-0
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发表时间：
1999-07-01
影响因子：
17.8
通讯作者：
Fini, ME
中科院分区：
文献类型：
--
作者：
Fini, ME
在哺乳动物中，组织损伤通常通过激活纤维化反应来修复，这可以挽救生物体的生命，但永远不能恢复受损器官的功能。此外，纤维化反应形成了多种病理的基础，包括许多发生在眼睛的病理。因此，观察哺乳动物中偶尔出现的修复具有再生特征的情况，如胎儿伤口愈合或某些类型的角膜伤口，是很有趣的。本章的主题是再生或纤维化的选择在于成纤维细胞表型的控制。眼睛的角膜有几个特征，使其成为研究成纤维细胞表型特别有用的模型。本文讨论的研究发现，转录因子nf - κ B的激活失败是抑制角膜成纤维细胞激活的一种控制机制。进一步的证据表明，修复组织中成纤维细胞表型的转变不仅仅是基因表达差异的问题，而是一个发育事件，反映了细胞对环境输入作出反应的信号通路的硬接线的变化。1999爱思唯尔科学有限公司阿里版权所有。
In mammals, tissue damage is usually repaired by activation of a fibrotic response which saves the life of the organism, but which can never restore function to the damaged organ. In addition, fibrotic responses form the basis for diverse pathologies, including many that occur in the eye. it is intriguing, therefore, to observe the occasional circumstances in which repair in mammals appears to take on a regenerative character, such as during fetal wound healing or in certain types of corneal wounds. The thesis of this chapter is that the choice between regeneration or fibrosis lies in the control of fibroblast phenotype. The cornea of the eye has several features which make it a particularly useful model for the study of fibroblast phenotype. Studies discussed herein, identify failure to activate the transcription factor NF-kappa B as a control mechanism for inhibiting fibroblast activation in the cornea. Evidence is further presented for the view that transition in fibroblast phenotype in repair tissue is not simply a matter of differential gene expression, but is a developmental event which reflects changes in the hard wiring of signalling pathways by which the cell responds to environmental input. (C) 1999 Elsevier Science Ltd. Ali rights reserved.