In situ decorating of ultrasmall Ag2Se on upconversion nanoparticles as novel nanotheranostic agent for multimodal imaging-guided cancer photothermal therapy
In situ decorating of ultrasmall Ag2Se on upconversion nanoparticles as novel nanotheranostic agent for multimodal imaging-guided cancer photothermal therapy
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超小型 Ag2Se 在上转换纳米颗粒上的原位修饰作为多模态成像引导癌症光热治疗的新型纳米治疗剂
DOI：
10.1016/japmt.2019.100497
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发表时间：
2020-03-01
影响因子：
8.3
通讯作者：
Zhang, Hongjie
中科院分区：
文献类型：
--
作者：
Du, Kaimin;Lei, Pengpeng;Zhang, Hongjie
通过在壳聚糖(CS)包覆的NaYF4：Yb/Er@NaLuF4：Nd/Yb@NaLuF4上转换纳米粒子(UCNPs)表面原位生长超小的Ag2Se纳米粒子，制备了一种新型的多功能热敏纳米平台。NaYF4：Yb/Er@NaLuF4：Nd/Yb@NaLuF4@CS@Ag2Se(标记为UCNPS@CS@Ag2Se)纳米复合材料在808 nm连续激光激发下，可以同时在近红外生物窗口I和II中提供下移(DS)和上转换(UC)发光。同时，附着的Ag2Se纳米点具有较强的近红外(NIR)吸收能力，在808 nm激光照射下可产生热能和光声能量。该纳米复合材料具有优异的发光性能、较高的X射线衰减系数和较强的近红外吸收特性，结合稀土元素对X射线的吸收特性，可作为一种智能对比剂用于体内外上转换发光(UCL)/下移发光(DSL)/计算机层析成像(CT)/光声(PA)多模式成像。此外，所合成的纳米复合材料具有优异的光热性能、良好的生物相容性和可忽略的毒性，显示出作为理想的光热疗法(PTT)试剂的巨大潜力。这些突出的性质表明，UCNPs@CS@Ag2Se纳米复合材料在四模成像引导的肿瘤PTT中具有很好的治疗效果。(C)2019爱思唯尔有限公司。保留所有权利。
A novel multifunctional theranostic nanoplatform was fabricated via in situ growth of ultrasmall Ag2Se nanodots on the surface of chitosan (CS) coated NaYF4:Yb/Er@NaLuF4:Nd/Yb@NaLuF4 upconversion nanoparticles (UCNPs). NaYF4:Yb/Er@NaLuF4:Nd/Yb@NaLuF4@CS@Ag2Se (labeled as UCNPs@CS@Ag2Se) nanocomposites can provide downshifting (DS) and upconversion (UC) luminescence in NIR biological window I and II under 808-nm continuous-wave laser excitation simultaneously. Meanwhile, the attached Ag2Se nanodots could produce hyperthermia and photoacoustic energy upon 808-nm laser irradiation due to its strong near-infrared (NIR) absorbance. Together with the X-ray absorbance feature of lanthanide components, the nanocomposites with excellent luminescent properties, high X-ray attenuation coefficient and strong NIR absorbance could be utilized as a smart contrast agent for upconversion luminescence (UCL)/downshifting luminescence (DSL)/computer tomography (CT)/photoacoustic (PA) multimodal imaging in vitro and in vivo. Furthermore, the as-synthesized nanocomposites possess superior photothermal performance, good biocompatibility, and negligible toxicity, showing great potential as an ideal photothermal therapy (PTT) agent. These outstanding properties revealed that UCNPs@CS@Ag2Se nanocomposites are promising theranostic agents for tetra-modal imaging-guided PTT of cancer. (C) 2019 Elsevier Ltd. All rights reserved.