IgM-forming cells as the immediate precursor of IgA-producing cells during ontogeny of the immunoglobulin-producing system of the chicken.
IgM-forming cells as the immediate precursor of IgA-producing cells during ontogeny of the immunoglobulin-producing system of the chicken.
复制标题
在鸡免疫球蛋白生成系统的个体发育过程中，IgM 形成细胞是 IgA 生成细胞的直接前体。
DOI：
10.4049/jimmunol.113.1.120
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发表时间：
1974
影响因子：
4.4
通讯作者：
G. Leslie
中科院分区：
文献类型：
--
作者：
Louis N. Martin;G. Leslie
在孵化时切除法氏囊并用抗α或抗μ抗体处理的鸡血清中IgM和伊加水平均降低，而IgY的产生不受影响。在孵化时切除法氏囊并用抗-α +抗-μ联合治疗的鸡比单独用任一抗体治疗的切除法氏囊的鸡具有更严重的血清IgM和伊加水平降低。抗-μ抗体对伊加的抑制作用，抗-α抗体对IgM的抑制作用，以及联合抗体处理对IgM和伊加的叠加抑制作用表明，IgA产生细胞是通过双重产生中间体从IgM形成前体细胞衍生而来的。在具有IgM和伊加严重抑制的鸟类中缺乏对IgY产生的抑制作用表明，很少（如果有的话）IgY形成细胞充当IgA产生细胞的前体。
Chickens bursećtomized at hatch and treated with either anti-α or anti-µ had depressed serum levels of both IgM and IgA, whereas IgY production was unaffected. Chickens bursectomized at hatch and treated with anti-α + anti-µ combined had more severely depressed levels of serum IgM and IgA than bursectomized chickens treated with either antibody alone. The suppressive effects of anti-µ on IgA, anti-α on IgM, and the the additive suppressive effect of combined antibody treatment on both IgM and IgA suggest that IgA-producing cells are derived from IgM-forming precursor cells through a doubly-producing intermediate. The lack of suppressive effect on IgY production in birds having severe depression of IgM and IgA indicates that few if any IgY-forming cells serve as precursors for IgA-producing cells.