Programming effects of short prenatal exposure to dexamethasone in sheep
Programming effects of short prenatal exposure to dexamethasone in sheep
复制标题
DOI：
10.1161/01.hyp.0000036455.62159.7e
复制
发表时间：
2002-11-01
期刊：
影响因子：
8.3
通讯作者：
Moritz, KM
中科院分区：
文献类型：
--
作者：
Dodic, M;Abouantoun, T;Moritz, KM
最近的研究表明，胎儿暴露于次优的宫内环境与成人高血压有关。本研究的目的是观察在妊娠26至28天之间对母羊静脉注射产前地塞米松（1）是否会导致雄性和雌性后代的高血压，以及雄性高血压是否受睾酮状态的调节，和（2）妊娠晚期和成人脑中血管紧张素原和血管紧张素1型（AT（1））受体的基因表达改变。出生前接触地塞米松的受试者（D组; 106 ± 5 mm Hg，n = 9）2岁时的基础平均动脉压（MAP）显著高于对照组（S组; 91 ± 3 mm Hg，n = 8; P
Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in, high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT(1)) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106+/-5 mm Hg, n = 9) compared with the control group (group S; 91+/-3 mm Hg, n = 8; P