Development of a Si-PM-based high-resolution PET system for small animals
Development of a Si-PM-based high-resolution PET system for small animals
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DOI：
10.1088/0031-9155/55/19/013
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发表时间：
2010-10-07
影响因子：
3.5
通讯作者：
Hatazawa, Jun
中科院分区：
文献类型：
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作者：
Yamamoto, Seiichi;Imaizumi, Masao;Hatazawa, Jun
盖革模式雪崩光电二极管（Si-PM）是一种很有前途的PET光电探测器，特别是用于磁共振成像（MRI）系统，因为它具有高增益，对静态磁场不太敏感。我们开发了一个基于硅-PM的相互作用深度（DOI）PET系统的小动物。Hamamatsu 4 x 4 Si-PM阵列（S11065- 025 P）用于其探测器块。0.75摩尔% Ce（衰减时间：类似于45 ns; 1.1 mm x 1.2 mm x 5 mm）和0.025摩尔% Ce（衰减时间：类似于31 ns; 1.1 mm x 1.2 mm x 6 mm）的两种类型的LGSO闪烁体在DOI方向上光学耦合以形成DOI检测器，其以11 x 9矩阵布置，并且光学耦合到Si-PM阵列。脉冲形状分析用于这两种类型的LGSO的DOI检测。16个探测器块被布置在68 mm直径的环中以形成PET系统。空间分辨率为1.6 mm FWHM，视场中心的灵敏度为0.6%。使用PET系统成功地获得了高分辨率的小鼠和大鼠图像。我们证实，所开发的基于Si-PM的PET系统是有前途的分子成像研究。
A Geiger-mode avalanche photodiode (Si-PM) is a promising photodetector for PET, especially for use in a magnetic resonance imaging (MRI) system, because it has high gain and is less sensitive to a static magnetic field. We developed a Si-PM-based depth-of-interaction (DOI) PET system for small animals. Hamamatsu 4 x 4 Si-PM arrays (S11065-025P) were used for its detector blocks. Two types of LGSO scintillator of 0.75 mol% Ce (decay time: similar to 45 ns; 1.1 mm x 1.2 mm x 5 mm) and 0.025 mol% Ce (decay time: similar to 31 ns; 1.1 mm x 1.2 mm x 6 mm) were optically coupled in the DOI direction to form a DOI detector, arranged in a 11 x 9 matrix, and optically coupled to the Si-PM array. Pulse shape analysis was used for the DOI detection of these two types of LGSOs. Sixteen detector blocks were arranged in a 68 mm diameter ring to form the PET system. Spatial resolution was 1.6 mm FWHM and sensitivity was 0.6% at the center of the field of view. High-resolution mouse and rat images were successfully obtained using the PET system. We confirmed that the developed Si-PM-based PET system is promising for molecular imaging research.