Release behavior of high molecular weight solutes from poly(ethylene glycol)-based degradable networks
Release behavior of high molecular weight solutes from poly(ethylene glycol)-based degradable networks
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DOI：
10.1021/ma9915024
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发表时间：
2000-04-04
期刊：
影响因子：
5.5
通讯作者：
Anseth, KS
中科院分区：
文献类型：
--
作者：
Lu, SX;Anseth, KS
合成了含有可水解α-羟基酸低聚嵌段的水溶性基于PEG的大分子单体，并进行光聚合以形成可降解的水凝胶，以控制高分子量亲水性溶质的释放。首先，对降解过程中的网络网格尺寸和体积溶胀比进行表征，以从根本上了解水凝胶降解动力学和网络结构的后续变化对溶质释放的影响。其次，检查了释放行为并与水凝胶的膨胀和结构特性相关；实验结果表明，根据水凝胶网格尺寸与溶质的相对大小，可以控制扩散或降解控制溶质传输。最后，从理论上研究了调整多层可生物降解水凝胶的释放以获得近似零级释放曲线的能力。
Water-soluble PEG-based macromers containing oligomeric blocks of a hydrolyzable alpha-hydroxy acid were synthesized and photopolymerized to form degradable hydrogels to control the release of high molecular weight, hydrophilic solutes. First, network mesh size and volume swelling ratio during the degradation process were characterized to understand fundamentally the effect of hydrogel degradation kinetics and subsequent changes in network structure on solute release. Second, the release behavior was examined and related to the swelling and structural properties of the hydrogels; experimental results show that solute transport can be diffusion controlled or degradation controlled depending on the relative size of the hydrogel mesh size to the solute. Finally, the ability to tailor the release from multilaminated biodegradable hydrogels to obtain an approximate zero-order release profile was studied theoretically.