Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome
Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome
复制标题
卵泡液可溶性晚期糖基化终末产物受体 (sRAGE)：在多囊卵巢综合征中的潜在保护作用
DOI：
10.1007/s10815-016-0704-6
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发表时间：
2016
影响因子：
3.1
通讯作者：
YiHong Guo
中科院分区：
文献类型：
--
作者：
BiJun Wang;MengMeng Hao;QingLing Yang;Jing Li;YiHong Guo
目的：探讨晚期糖基化终产物可溶性受体(SRAGE)与体外受精-胚胎移植(IVF-ET)结局参数的关系，探讨sRAGE在PCOS发病过程中的炎症保护作用。方法：对郑州大学附属第一医院生殖医学中心74名受试者进行前瞻性研究。我们对39例多囊卵巢综合征和35例非多囊卵巢综合征育龄妇女卵泡液中sRAGE、血管内皮生长因子、肿瘤坏死因子、白细胞介素6和C反应蛋白的水平进行了定量研究。结果：PCOS组卵泡液中sRAGE水平明显低于对照组，而PCOS组卵泡液中sRAGE、α、IL-6、CRP值显著高于对照组(P<0.05)。体外受精组sRAGE与促性腺激素总量(Gn)呈显著负相关(r=-0.451，P=0.004)。调整年龄和Gn剂量后，卵泡液中sRAGE蛋白水平与血管内皮生长因子(r=-0.378，P=0.018)、肿瘤坏死因子-α(r=-0.450，P=0.004)、IL-6(r=-0.455，P=0.004)和C反应蛋白(r=-0.375，P=0.019)呈负相关。
PURPOSE:To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding inflammation..METHODS:We conducted a prospective analysis of a subsample of 74 participants from the Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University. We quantified sRAGE, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukelin-6 (IL-6), and C-reactive protein (CPR) protein levels in the follicular fluid from 39 PCOS and 35 non-PCOS reproductive-age women. sRAGE and VEGF, TNF-α, IL-6, and CRP in follicular fluid aspirated without blood were measured by ELISA..RESULTS:sRAGE concentrations in the follicular fluid were significantly lower in the PCOS group compared to those in the control group, while VEGF, TNF-α, IL-6, and CRP concentrations were significantly higher in the PCOS group than in the control group (P < 0.05). sRAGE was significantly, inversely correlated with the total dose of gonadotropin (Gn) in the PCOS group undergoing IVF treatment (r = -0.451, P = 0.004). After adjusting for age and Gn dose (in international units used per cycle), sRAGE protein levels in the follicular fluid were significantly, inversely related to VEGF (r = -0.378, P = 0.018), TNF-α (r = -0.450, P = 0.004), IL-6 (r = -0.455, P = 0.004), and CRP (r = -0.375, P = 0.019)..CONCLUSION:sRAGE in the follicular fluid might exert a protective effect against the inflammatory action of PCOS development.