Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension.
Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension.
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通过体动记录仪测量患有肺动脉高压的婴儿和幼儿的体力活动。
DOI：
10.1016/j.jpeds.2023.113639
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Ivy,DDunbar
中科院分区：
文献类型：
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作者：
Avitabile,CatherineM;Yung,Delphine;Handler,Stephanie;Hopper,RachelK;Fineman,Jeff;Freire,Grace;Varghese,Nidhy;Mullen,MaryP;Krishnan,UshaS;Austin,Eric;Silveira,Lori;Ivy,DDunbar
目的评价可穿戴式体动仪在肺动脉高压（PAH）婴幼儿中的可行性、耐受性和依从性。研究设计本多中心、前瞻性、观察性研究包括0-6岁PAH和非PAH儿童。参与者在14天的清醒时间内在臀部佩戴ActiGraph wGT 3X-BT，在手腕上佩戴FitBit Mixire。步骤，每分钟的向量幅度计数，活动强度，心率，心率变异性进行了比较groups. ResultsForty七名参与者（18 PAH，29控制）从10个北美网站。PAH患者大多为功能II级（n = 16，89%），在入组时接受口服药物治疗。两组之间的佩戴天数无显著差异（ActiGraph：PAH组10 [95% CI：5.5，12.2] vs对照组8 [4，12]，P= 0.20; FitBit：PAH组13 [10，13.8] vs对照组12 [8，14]，P= 0.87）。在81%的合格ActiGraph参与者和72%的FitBit参与者中获得了完整的数据。与对照组参与者相比，PAH参与者的步数更少，每分钟的矢量幅度计数更低，久坐活动更多，所有级别的体力活动强度更低。心率变异性无统计学显着差异，证明2 groups.ConclusionsMeasurement身体活动和其他终点使用可穿戴体动仪设备在PAH的幼儿是可行的。大型研究应确定年轻PAH患者体力活动与疾病严重程度之间的相关性，以确定儿科临床试验的相关终点。
ObjectiveTo evaluate the feasibility, tolerability, and adherence with wearable actigraphy devices among infants and children with pulmonary arterial hypertension (PAH).Study designThis multicenter, prospective, observational study included children ages 0-6 years with and without PAH. Participants wore the ActiGraph wGT3X-BT on the hip and FitBit Inspire on the wrist during waking hours for 14 days. Steps, vector magnitude counts per minute, activity intensity, heart rate, and heart rate variability were compared between groups.ResultsForty-seven participants (18 PAH, 29 control) were enrolled from 10 North American sites. PAH patients were mostly functional class II (n = 16, 89%) and treated with oral medications at the time of enrollment. The number of wear days was not significantly different between the groups (ActiGraph: 10 [95% CI: 5.5, 12.2] in PAH vs 8 [4, 12] in control,P= .20; FitBit 13 [10, 13.8] in PAH vs 12 [8, 14] in control,P= .87). Complete data were obtained in 81% of eligible ActiGraph participants and 72% of FitBit participants. PAH participants demonstrated fewer steps, lower vector magnitude counts per minute, more sedentary activity, and less intense physical activity at all levels compared with control participants. No statistically significant differences in heart rate variability were demonstrated between the 2 groups.ConclusionsMeasurement of physical activity and other end points using wearable actigraphy devices was feasible in young children with PAH. Larger studies should determine associations between physical activity and disease severity in young patients with PAH to identify relevant end points for pediatric clinical trials.