A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery
A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery
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DOI：
10.1016/j.jclinane.2016.01.010
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发表时间：
2016-06-01
影响因子：
6.7
通讯作者：
Obata, Hideaki
中科院分区：
文献类型：
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作者：
Fujita, Nao;Tobe, Masaru;Obata, Hideaki
研究目的：探讨腰椎后路植骨融合术前一次性应用两种不同剂量的普瑞巴林(75 mg和150 mg)能否减少术后疼痛强度和阿片类药物的消耗。设计：前瞻性、随机化、积极安慰剂对照、双盲研究。地点：术后恢复区和患者房间。患者：97名成人，美国麻醉学家协会1和2名患者。干预：患者被随机分为地西潘5 mg作为活性安慰剂(D5)、普瑞巴林75 mg(P75)或普瑞加巴林150 mg(P150)。研究药物在手术前2小时口服，并使用标准的麻醉技术。术后疼痛采用吗啡静脉病人自控镇痛。测量：在麻醉后监护病房拔管后即刻，术后2，4，6，12，18，24，36，48h采用静息视觉模拟评分法测量疼痛强度。直到术后48小时评估吗啡的用量和不良反应。主要结果：P150组静息视觉模拟评分低于D5组，直到术后2小时。术后0~12h，P150组吗啡用量低于D5组。结论：腰椎后路植骨融合术患者术前2小时单次应用150 mg普瑞巴林可降低术后疼痛强度和吗啡用量。(C)2016 Elsevier Inc.保留所有权利。
Study objective: To determine whether single preoperative administration of 2 different doses of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid consumption following posterior lumbar interbody fusion surgery.Design: Prospective, randomized, active placebo-controlled, double-blinded study.Setting: Postoperative recovery area and patients' room.Patients: Ninety-seven adult, American Society of Anesthesiologists physical status 1 and 2 patients.Interventions: Patients were randomly assigned to receive diazepam 5 mg as an active placebo (D5), pregabalin 75 mg (P75), or pregabalin 150 mg (P150). The study drug was orally administered 2 hours prior to surgery and a standard anesthetic technique was used. Postoperative pain was managed using intravenous patient-controlled analgesia with morphine.Measurement: The visual analog scale at rest was used to measure pain intensity immediately after extubation at the postanesthesia care unit, and then 2, 4, 6, 12, 18, 24, 36, and 48 hours after surgery. Morphine consumption and adverse effects were assessed until 48 hours after surgery. Main results: The visual analog scale score at rest was lower in the P150 group than in the D5 group until 2 hours after surgery. Morphine consumption was lower in the P150 group than in the D5 from 0 to 12 hours after surgery.Conclusions: Single preoperative administration of 150 mg of pregabalin 2 hours prior to surgery reduced postoperative pain intensity and morphine consumption compared with 5 mg diazepam in patients who underwent posterior lumbar interbody fusion. (C) 2016 Elsevier Inc. All rights reserved.