Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism
Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism
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DOI：
10.1186/1471-244x-8-66
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发表时间：
2008-08-01
期刊：
影响因子：
4.4
通讯作者：
Rogers, Sally J.
中科院分区：
文献类型：
--
作者：
Rojas, Donald C.;Maharajh, Keeran;Rogers, Sally J.
背景：从人类电生理记录中记录的伽马波段振荡，可能与感知绑定和神经元连接有关，已被证明在自闭症患者中发生了改变。然而，暂时的听觉伽玛带反应尚未在自闭症患者或自闭症患者的一级亲属中进行研究。方法：对16名自闭症儿童家长、11名自闭症成人家长和16名对照组的脑磁图记录进行瞬态诱发和诱导磁伽马带功率和锁相一致性的测量。源空间投影用于分离左右半球功率和锁相瞬态伽马波段测量。结果：父母组和自闭症组的诱发γ波段功率明显高于对照组，诱发γ波段功率明显低于对照组。锁相因子（一种衡量神经元对外部刺激反应相一致性的指标）在自闭症受试者和自闭症父母组中明显较低，这可能解释了诱发功率和诱导功率结果之间的差异。结论：这些发现，特别是在一级亲属中，表明伽马波段相位一致性和诱导与诱导功率的变化可能是自闭症潜在的有用的内表型，特别是考虑到伽马波段信号产生的新兴分子机制。
Background: Gamma-band oscillations recorded from human electrophysiological recordings, which may be associated with perceptual binding and neuronal connectivity, have been shown to be altered in people with autism. Transient auditory gamma-band responses, however, have not yet been investigated in autism or in the first-degree relatives of persons with the autism.Methods: We measured transient evoked and induced magnetic gamma-band power and intertrial phase-locking consistency in the magnetoencephalographic recordings of 16 parents of children with autism, 11 adults with autism and 16 control participants. Source space projection was used to separate left and right hemisphere transient gamma-band measures of power and phase-locking.Results: Induced gamma-power at 40 Hz was significantly higher in the parent and autism groups than in controls, while evoked gamma-band power was reduced compared to controls. The phaselocking factor, a measure of phase consistency of neuronal responses with external stimuli, was significantly lower in the subjects with autism and the autism parent group, potentially explaining the difference between the evoked and induced power results.Conclusion: These findings, especially in first degree relatives, suggest that gamma-band phase consistency and changes in induced versus induced power may be potentially useful endophenotypes for autism, particularly given emerging molecular mechanisms concerning the generation of gamma-band signals.