Mortality associated with influenza and respiratory syncytial virus in the United States
Mortality associated with influenza and respiratory syncytial virus in the United States
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DOI：
10.1001/jama.289.2.179
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发表时间：
2003-01-08
影响因子：
120.7
通讯作者：
Fukuda, K
中科院分区：
文献类型：
--
作者：
Thompson, WW;Shay, DK;Fukuda, K
流感和呼吸道合胞病毒（RSV）导致大量的发病率和死亡率。用于估计美国流感死亡的统计方法没有考虑RSV的传播。目的使用全国死亡率和病毒监测数据建立统计模型，按年龄组、病毒、流感类型和亚型估计美国每年流感和RSV相关死亡。设计，设置，使用1976-1977年至1998-1999年流感季节的国家病毒监测数据，使用人群特异性泊松回归模型估计流感相关死亡。同时估计了1990-1991年至1998-1999年流感季节流感和RSV相关的死亡。主要结果测量3类归因死亡：基础肺炎和流感，基础呼吸和循环，结果1976-1977年和1998年之间流感相关死亡的年度估计数显著增加，1999年所有3种死亡类别的季节（P
Context Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation.Objective To develop a statistical model using national mortality and viral surveillance data to estimate annual influenza- and RSV-associated deaths in the United States, by age group, virus, and influenza type and subtype.Design, Setting, and Population Age-specific Poisson regression models using national viral surveillance data for the 1976-1977 through 1998-1999 seasons were used to estimate influenza-associated deaths. Influenza- and RSV-associated deaths were simultaneously estimated for the 1990-1991 through 1998-1999 seasons.Main Outcome Measures Attributable deaths for 3 categories: underlying pneumonia and influenza, underlying respiratory and circulatory, and all causes.Results Annual estimates of influenza-associated deaths increased significantly between the 1976-1977 and 1998-1999 seasons for all 3 death categories (P