Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease
Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease
复制标题
DOI：
10.1007/s10072-003-0115-1
复制
发表时间：
2003-10-01
影响因子：
3.3
通讯作者：
Stanzione, P
中科院分区：
文献类型：
--
作者：
de Michele, F;Longone, P;Stanzione, P
使用气相色谱/质谱法对 11 名帕金森病 (PD) 患者（第 1 组）的血浆和 12 名帕金森病 (PD) 患者的酒液中神经活性类固醇四氢孕酮 (THP) 和 5α-二氢孕酮 (DHP) 的水平进行了定量。与对照组相比，两组的 DHP 和 THP 浓度均显着降低。这些下降可能是 PD 的一个有用标志。此外，鉴于 GABA 能传递对黑质 (SN) 神经元的重要性以及两种神经活性类固醇施加的 GABA 能调节的重要性，我们的数据表明 PD 患者中 SN GABA 能系统的整体失调。此外，DHP 促进的神经保护因子（即 GDNF、BDNF）的缺乏可能导致多巴胺能细胞死亡。
The levels of the neuroactive steroids allopregnanolone (THP) and 5alpha-dihydroprogesterone (DHP) were quantified in the plasma of 11 (group 1) and in the liquor of 12 (group 2) Parkinson's disease (PD) patients using a gas-chromatographic/mass-spectrometric method. When compared with controls, both groups showed a significant decrease in DHP and THP concentrations. These decreases could be a useful marker of PD. Moreover, in view of the importance of GABA-ergic transmission to substantia nigra (SN) neurons and GABA-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the SN GABA-ergic system in PD patients. Moreover, a lack of neuroprotective factors (i.e., GDNF, BDNF), promoted by DHP, may contribute to dopaminergic cell death.