Spontaneous Oscillatory Rhythms in the Degenerating Mouse Retina Modulate Retinal Ganglion Cell Responses to Electrical Stimulation.
Spontaneous Oscillatory Rhythms in the Degenerating Mouse Retina Modulate Retinal Ganglion Cell Responses to Electrical Stimulation.
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DOI：
10.3389/fncel.2015.00512
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发表时间：
2015
影响因子：
5.3
通讯作者：
Senok SS
中科院分区：
文献类型：
--
作者：
Goo YS;Park DJ;Ahn JR;Senok SS
在视网膜变性的动物模型中进行视网膜电活动的表征部分地是为了理解视网膜变性疾病如年龄相关性黄斑变性（AMD）和色素性视网膜炎（RP）的进展，而且也是为了确定用于视网膜假体装置的最佳刺激范例。在这方面研究最多的模型是磷酸二酯酶β亚基缺陷的两个小鼠品系（rd 1和rd 10小鼠），其中退化的视网膜表现出特征性的自发性活动过度和振荡局部场电位（LFP）。此外，在振荡LFP的波谷上存在视网膜神经节细胞（RGC）尖峰的稳健的~10 Hz节律性爆发。在rd 1小鼠中，RGC尖峰的节律性爆发总是与振荡LFP锁相，并且无论出生后年龄如何，这种锁相特性都被保留。然而，在rd 10小鼠中，振荡节律的频率根据出生后的年龄而变化，这表明这种节律可能是退化阶段的标志。此外，当双相电流刺激施加到rd 10小鼠退化的视网膜时，出现与退化阶段相关的不同RGC响应模式。这篇评论还认为这些响应特性的意义。
Characterization of the electrical activity of the retina in the animal models of retinal degeneration has been carried out in part to understand the progression of retinal degenerative diseases like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), but also to determine optimum stimulus paradigms for use with retinal prosthetic devices. The models most studied in this regard have been the two lines of mice deficient in the β-subunit of phosphodiesterase (rd1 and rd10 mice), where the degenerating retinas exhibit characteristic spontaneous hyperactivity and oscillatory local field potentials (LFPs). Additionally, there is a robust ~10 Hz rhythmic burst of retinal ganglion cell (RGC) spikes on the trough of the oscillatory LFP. In rd1 mice, the rhythmic burst of RGC spikes is always phase-locked with the oscillatory LFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, the frequency of the oscillatory rhythm changes according to postnatal age, suggesting that this rhythm might be a marker of the stage of degeneration. Furthermore when a biphasic current stimulus is applied to rd10 mice degenerate retina, distinct RGC response patterns that correlate with the stage of degeneration emerge. This review also considers the significance of these response properties.