Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
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DOI：
10.1093/ntr/ntx107
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发表时间：
2018-04-01
影响因子：
4.7
通讯作者：
Kaplan, Robert C.
中科院分区：
文献类型：
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作者：
Saccone, Nancy L.;Emery, Leslie S.;Kaplan, Robert C.
引言：先前已经确定了与尼古丁依赖相关的遗传变异，主要是在欧洲血统人群中。没有全基因组关联研究（GWAS）报告了美国和拉丁美洲的西班牙裔/拉丁美洲人的吸烟行为，他们是欧洲，非洲和美洲土著成分的混合祖先。方法：我们在西班牙裔社区健康研究/拉丁裔研究中检查了吸烟行为的遗传关联（HCHS/SOL）（N = 12 741，有吸烟数据，5119例曾吸烟者），使用类似的230万个基因型变异，估算到1000个基因组项目第3阶段。混合逻辑回归模型解释了人口结构、抽样、相关性、性别和年龄。结果：CHRNA 5的已知区域，编码α 5胆碱能烟碱受体亚单位，与全基因组意义上的重度吸烟相关（p 10 vs 3156报告CPD
Introduction: Genetic variants associated with nicotine dependence have previously been identified, primarily in European-ancestry populations. No genome-wide association studies (GWAS) have been reported for smoking behaviors in Hispanics/Latinos in the United States and Latin America, who are of mixed ancestry with European, African, and American Indigenous components.Methods: We examined genetic associations with smoking behaviors in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (N = 12 741 with smoking data, 5119 ever-smokers), using similar to 2.3 million genotyped variants imputed to the 1000 Genomes Project phase 3. Mixed logistic regression models accounted for population structure, sampling, relatedness, sex, and age.Results: The known region of CHRNA5, which encodes the alpha 5 cholinergic nicotinic receptor subunit, was associated with heavy smoking at genome-wide significance (p 10 versus 3156 reporting CPD