The negative regulators of the host immune response: an unexplored pathway in preterm birth.
The negative regulators of the host immune response: an unexplored pathway in preterm birth.
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DOI：
10.1016/j.ajog.2009.05.053
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发表时间：
2009-09
影响因子：
9.8
通讯作者：
Elovitz MA
中科院分区：
文献类型：
--
作者：
Lyttle B;Chai J;Gonzalez JM;Xu H;Sammel M;Elovitz MA
toll样受体是宿主免疫的重要介质。TLR的激活必须严格调节，以防止过度的免疫反应破坏宿主。这些研究评估了负调节因子（IRAK-3, IRAK-1， FADD）在妊娠和早产（PTB）中的表达。取各组子宫、子宫颈、胎盘、脾脏组织：1)未妊娠小鼠，2)跨妊娠小鼠，3)PTB小鼠模型，4)暴露于醋酸甲羟孕酮（MPA）的妊娠小鼠。负调节因子在怀孕期间在子宫中有差异表达。在PTB的情况下，IRAK-3在子宫和子宫颈显著增加，但在胎盘中没有。在母体脾脏中，IRAK-3和IRAK-1在宫内炎症反应中升高。MPA可增加宫颈组织中IRAK的表达。母体免疫反应的负调节因子可能在保护妊娠免受夸张的炎症反应中发挥重要作用。
Toll-like receptors are essential mediators of host immunity. TLR activation must be tightly regulated to prevent an exaggerated immune response from devastating the host. These studies assessed the expression of negative regulators (IRAK-3, IRAK-1, FADD) during pregnancy and in preterm birth (PTB). Tissues (uterine, cervix, placenta and spleens) from the following experimental groups were harvested: 1) non-pregnant mice, 2) pregnant mice across gestation, 3) murine model of PTB, and 4) pregnant mice exposed to medroxyprogesterone acetate (MPA). Negative regulators are differentially expressed in the uterus during pregnancy. In the setting of PTB, IRAK-3 is significantly increased in the uterus and cervix, but not the placenta. In maternal spleens, IRAK-3 and IRAK-1 are increased in response to intrauterine inflammation. MPA can increase IRAK expression in cervical tissues. Negative regulators of the maternal immune response may play an important role in protecting pregnancies from an exaggerated inflammatory response.
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DOI：
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发表时间：
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影响因子：
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发表时间：
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影响因子：
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作者：
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