The enigmatic parietal epithelial cell is finally getting noticed: a review.

The enigmatic parietal epithelial cell is finally getting noticed: a review.
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DOI:
10.1038/ki.2009.386
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发表时间:
2009-12
影响因子:
19.6
通讯作者:
Shankland, Stuart J.
Shankland, Stuart J.
中科院分区:
医学1区
文献类型:
--
作者:
Ohse, Takamoto;Pippin, Jeffrey W.;Chang, Alice M.;Krofft, Ronald D.;Miner, Jeffrey H.;Vaughan, Michael R.;Shankland, Stuart J.

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虽然正常肾小球包括四种常驻细胞类型,但对壁上皮细胞(佩奇)知之甚少。这篇全面的综述讨论了佩奇的细胞起源,讨论了佩奇的正常结构和蛋白质组成,描述了PEC的功能,并定义了对疾病损伤的反应以及这些事件如何导致临床事件。这些数据表明,佩奇具有独特的特性,并且正在认识到新的功能,例如它们在疾病期间分化为足细胞的作用。
Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease.
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