Tau protein as a serum marker of brain damage in mild traumatic brain injury: Preliminary results
Tau protein as a serum marker of brain damage in mild traumatic brain injury: Preliminary results
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DOI：
10.1007/bf02850342
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发表时间：
2006-01-01
影响因子：
3.8
通讯作者：
Parlak, M
中科院分区：
文献类型：
--
作者：
Bulut, M;Koksal, O;Parlak, M
本研究的目的是探讨血清tau蛋白在确定轻度创伤性脑损伤（mTBI）患者和高危患者的创伤性脑损伤严重程度中的诊断价值。前瞻性入组了1年以上因mTBI就诊于急诊科（艾德）的成人患者。患者接受了头颅计算机断层扫描（CT），并根据颅内损伤的可能性分为高风险组和低风险组。检测60例患者和20例健康志愿者的血清tau水平，并作为对照组。60例患者（45例男性，15例女性）的平均年龄为32.5岁（范围：15-66岁）。平均格拉斯哥昏迷量表（GCS）评分为14 +/- 0.6。CT显示颅内损伤11例（18.3%），凹陷性骨折4例（6.7%）。与对照组（86 - 48 pg/mL）相比，患者的血清tau水平（188 +/- 210 pg/mL）相对较高;然而，差异无统计学意义（P = 0.445）。
The objective of this study was to investigate the diagnostic value of serum tau protein in determining the severity of traumatic brain injury in patients with mild traumatic brain injury (mTBI) and high-risk patients. Adult patients who presented to our emergency department (ED) with mTBI over I year were prospectively enrolled. Patients underwent cranial computed tomography (CT) and were subdivided into high- and low-risk groups, according to the probability of resultant intracranial injury. Serum tau levels of 60 patients and 20 healthy volunteers, who served as a control group, were measured. The mean age of the 60 patients (45 males, 15 females) was 32.5 years (range, 15-66 y). Mean Glasgow Coma Scale (GCS) score was 14 +/- 0.6. CT scans demonstrated intracranial injury in 11 patients (18.3%) and depressed fracture in 4 patients (6.7%). Serum tau levels of patients (188 +/- 210 pg/mL), compared with those of controls (86 48 pg/mL), were relatively higher; however, differences were not statistically significant (P = .445).