EFFECT OF ANDROGENS ON ERYTHROID AND GRANULOCYTIC MARROW RECOVERY IN IRRADIATED RAT
EFFECT OF ANDROGENS ON ERYTHROID AND GRANULOCYTIC MARROW RECOVERY IN IRRADIATED RAT
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DOI：
10.1159/000208474
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发表时间：
1972-01-01
影响因子：
2.4
通讯作者：
PRICE, DC
中科院分区：
文献类型：
--
作者：
HORN, Y;PRICE, DC
本文研究了睾酮对照射后大鼠骨髓和循环粒细胞恢复的影响。替吉奥加速外周血多形核白细胞的恢复，如果在照射前开始治疗，则更是如此。与对照组相比，骨髓59 Fe的增加证实了睾酮的同时红细胞刺激作用。还注意到在所有照射组中骨髓中的99 Tcm-硫胶体摄取增加，而没有不同的睾酮效应，这可能反映了照射后血管分布增加的恢复反应。讨论了可能的机制。
A study was performed on the effect of testosterone on post-irradiation recovery of bone marrow and circulating granulocytes in the rat. Testosterone accelerated recovery of peripheral polymorphonuclear leukocytes, more so if therapy was initiated prior to irradiation. Increased marrow59Fe compared to controls confirmed the simultaneous erythroid stimulating effect of testosterone.99Tcm-sulfur colloid uptake in the marrow was also noted to be increased in all irradiated groups without a differential testosterone effect, perhaps reflecting a post-irradiation recovery response of increased vascularity. The possible mechanisms are discussed.