C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
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DOI：
10.1016/s0140-6736(05)67786-0
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发表时间：
2005-12-03
期刊：
影响因子：
168.9
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Timpson, NJ;Lawlor, DA;Smith, GD
背景：循环C反应蛋白（CRP）与代谢综合征相关，并可能与代谢综合征存在因果关系。我们的目的是评估血浆CRP与代谢综合征表型之间的相关性，这些表型不受混杂因素和反向因果关系的影响，方法我们在英国女性心脏病患者中检测了血清CRP浓度和代谢综合征表型之间的关系，健康研究。然后，我们比较了这些估计与来自孟德尔随机框架与常见的CRP基因单倍型产生unconfounded和公正的估计任何因果associations.Findings在英国妇女的样本中，体重指数（BMI），收缩压，腰臀比，高密度脂蛋白胆固醇和甘油三酯的血清浓度，和胰岛素抵抗与血浆CRP浓度。CRP单倍型与血浆CRP浓度相关（p
Background Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein.Methods We examined associations between serum CRP concentration and metabolic syndrome phenotypes in the British Women's Heart and Health Study. We then compared these estimates with those derived from a mendelian randomised framework with common CRP gene haplotypes to generate unconfounded and unbiased estimates of any causal associations.Findings In a sample of British women, body-mass index (BMI), systolic blood pressure, waist-to-hip ratio, serum concentrations of HDL cholesterol and triglycerides, and insulin resistance were all associated with plasma CRP concentration. CRP haplotypes were associated with plasma CRP concentration (p