DIVERGENT 7 TRANSMEMBRANE RECEPTORS ARE CANDIDATE CHEMOSENSORY RECEPTORS IN C-ELEGANS
DIVERGENT 7 TRANSMEMBRANE RECEPTORS ARE CANDIDATE CHEMOSENSORY RECEPTORS IN C-ELEGANS
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DOI：
10.1016/0092-8674(95)90162-0
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发表时间：
1995-10-20
期刊：
影响因子：
64.5
通讯作者：
BARGMANN, CI
中科院分区：
文献类型：
--
作者：
TROEMEL, ER;CHOU, JH;BARGMANN, CI
动物利用味觉和嗅觉识别各种化学物质，线虫只有14种化学感觉神经元，但它对数十种化学物质做出反应，因为每个化学感觉神经元都能检测到几种刺激。在这里，我们描述了40多个高度不同的G蛋白偶联受体家族成员，它们可能有助于这种功能多样性。这些候选受体基因大多位于两到九个相似基因的簇中。在测试的14个基因中，有11个似乎在化学感觉神经元的小亚群中表达。一种单一类型的化学感觉神经元可能至少表达四种不同的受体基因。其中一些基因可能编码水溶性引诱剂、驱虫剂和信息素的受体。
Using their senses of taste and smell, animals recognize a wide variety of chemicals, The nematode C. elegans has only fourteen types of chemosensory neurons, but it responds to dozens of chemicals, because each chemosensory neuron detects several stimuli. Here we describe over 40 highly divergent members of the G protein-coupled receptor family that could contribute to this functional diversity. Most of these candidate receptor genes are in clusters of two to nine similar genes. Eleven of fourteen tested genes appear to be expressed in small subsets of chemosensory neurons. A single type of chemosensory neuron can potentially express at least four different receptor genes. Some of these genes might encode receptors for water-soluble attractants, repellents, and pheromones.