Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.
Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.
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DOI：
10.1021/acsnano.8b06563
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发表时间：
2019-01
期刊：
影响因子：
17.1
通讯作者：
Fan Yang;A. Skripka;M. Tabatabaei;Sung Hwa Hong;F. Ren;A. Benayas;J. Oh;S. Martel;Xinyu Liu-Xinyu
中科院分区：
文献类型：
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作者：
Fan Yang;A. Skripka;M. Tabatabaei;Sung Hwa Hong;F. Ren;A. Benayas;J. Oh;S. Martel;Xinyu Liu-Xinyu
开发多功能治疗和诊断（治疗诊断）纳米平台对于解决与癌症相关的挑战性问题至关重要。在这里，自组装的超纳米粒子组成的超顺磁性Fe 3 O 4纳米粒子和光致发光的PbS/CdS量子点，其发射位于第二个生物窗口（II-BW）的开发。所提出的自组装Fe 3 O 4和PbS/CdS（II-BW）超纳米粒子[SASNs（II-BW）]通过克服II-BW中严重的光消光和伴随的自发荧光，表现出通过厚达14 mm的组织可检测的出色的光致发光，并且显著增强了T2弛豫率（282 mM-1 s-1，约1.5 μ m）。比游离Fe 3 O 4纳米颗粒高4倍），这是由于大大增强的磁场不均匀性。另一方面，SASNs（II-BW）具有双重能力，作为磁热和光热剂，分别克服了每种类型的加热的主要缺点。当SASNs（II-BW）暴露于双模式（磁热和光热）加热时，与单独的磁加热相比，热能传递效率放大了7倍。这些结果，与优异的光稳定性和胶体稳定性以及可忽略的细胞毒性一起，证明了SASNs（II-BW）用于深部组织双峰（磁共振和光致发光）体内成像的潜在用途，同时提供了SASNs（II-BW）介导的放大双模加热治疗用于癌症治疗的可能性。
Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photoluminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self-assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T2 relaxivity (282 mM-1 s-1, ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.