A five-year inhalation study with natural uranium dioxide (UO2) dust. II. Postexposure retention and biologic effects in the monkey, dog and rat.
A five-year inhalation study with natural uranium dioxide (UO2) dust. II. Postexposure retention and biologic effects in the monkey, dog and rat.
复制标题
一项为期五年的天然二氧化铀 (UO2) 粉尘吸入研究。
DOI：
10.1097/00004032-197309000-00003
复制
发表时间：
1973
期刊：
影响因子：
2.2
通讯作者：
H. B. Wilson
中科院分区：
文献类型：
--
作者：
L. J. Leach;C. Yuile;H. Hodge;G. Sylvester;H. B. Wilson
Inhalation studies show that dogs, monkeys, and rats can breathe a natural uranium dioxide aerosol of approximately 1 mu m mass median particle diameter at a mean concentration of 5 mg U/m/sup 3/ (25 x Threshold Limit Value or 28 x Maximum Permissible Concentration in Air) for periods as long as 5 yr with little evidence of serious injury (L. J. Leach et al., Health Phys. 18: postexposure periods during which pulmonary neoplasia developed in a high percentage of the dogs examined 2 to 6 yr after exposure. Pulmonary and tracheobronchial lymph node fibrosis, consistent with radiation effects, apparently dose dependent, and more marked in monkeys than in dogs was also noted. No evidence of uranium toxicity was found in records of body weights, mortality, various hematologic parameters, or the histologic condition of the kidneys. (auth)
