The differential effect of illicit drug use on cognitive function in first-episode psychosis and healthy controls
The differential effect of illicit drug use on cognitive function in first-episode psychosis and healthy controls
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DOI：
10.1111/j.1600-0447.2011.01803.x
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发表时间：
2012-05-01
影响因子：
6.7
通讯作者：
Doody, G. A.
中科院分区：
文献类型：
--
作者：
Donoghue, K.;Mazzoncini, R.;Doody, G. A.
目的：非法药物使用可导致健康人认知功能的损害。患有精神病的人也表现出认知功能的缺陷。吸毒可能只会导致精神病患者特有的认知缺陷，或者导致“双重缺陷”。本研究旨在调查首发精神病患者的药物使用与认知功能之间的关系，并与社区配对的对照组进行对照。方法：177名首发精神病患者完成了一系列的神经心理测试。前一年吸毒者(n=80)与前一年未吸毒者(n=97)进行比较。根据药物使用情况，将首发精神病患者的亚样本与社区匹配的对照组(n=110)进行比较。结果：首发精神病患者在神经心理测试中的表现与未使用药物的患者相同。相比之下，前一年使用过毒品的健康对照组在执行功能和工作记忆测试中的表现低于未使用过毒品的对照组。结论：首发精神病患者和健康对照组的非法药物滥用与认知功能存在不同的关联。
Objective: Illicit drug use can result in impairment in cognitive function in healthy individuals. Individuals with a psychotic disorder also show a deficit in cognitive function. Drug use may simply contribute to the characteristic cognitive deficit found in psychosis or alternatively result in a 'double deficit'. This study aims to investigate the association between drug use and cognitive function at the first-episode of psychosis and in community-matched controls.Method: One hundred and seventy-seven patients at the first episode of psychosis completed a battery of neuropsychological tests. Those that had used drugs in the previous year (n = 80) were compared with those who had not used drugs in the previous year (n = 97). A subsample of the first-episode psychosis patients were compared with community-matched controls (n = 110) according to drug-use status.Results: Patients with a first episode of psychosis who had used drugs performed equally to those who had not used drugs on neuropsychological tests. In contrast, healthy controls who had used drugs in the previous year performed worse on tests of executive function and working memory compared with those controls that had not used drugs.Conclusion: There are differential associations of illicit drug misuse with cognitive function for first-episode psychosis patients and healthy controls.