Genetic reconstruction and phylogenetic analysis by 193 Y-SNPs and 27 Y-STRs in a Chinese Yi ethnic group
Genetic reconstruction and phylogenetic analysis by 193 Y-SNPs and 27 Y-STRs in a Chinese Yi ethnic group
复制标题
中国彝族193个Y-SNP和27个Y-STR的遗传重建和系统发育分析
DOI：
10.1002/elps.202100003
复制
发表时间：
2021-05-05
期刊：
影响因子：
2.9
通讯作者：
Hou, Yiping
中科院分区：
文献类型：
--
作者：
Wang, Fei;Song, Feng;Hou, Yiping
彝族是中国第七大民族，具有山地地域特色。凉山彝族自治州是最大的彝族聚居区，地理条件与世隔绝，严重阻碍了基因交流。本研究对凉山地区427名无血缘关系的男性进行了193个Y染色体单核苷酸多态性（Y-SNPs）和27个Y染色体短串联重复序列（Y-STR）的遗传分析，以揭示凉山地区汉族人群的遗传结构和父系遗传关系。193个Y-SNPs位点的单倍型多样性为0.9169，46个亚单倍型，27个Y-STR位点的单倍型多样性为0.9999。通过多维尺度分析、N-J树分析和网络分析，揭示了彝族与世界各民族之间的遗传关系。我们的结果显示：（1）Y-STR和Y-SNPs网络分析表明凉山彝族D1 a1 a-M15单倍群是高原藏族群体自西向东扩展的产物，（2）单倍群分布和错配突变分析表明凉山彝族O2 a2 b1 a1 a1 a4 a2-Z25929单倍群来源于多个东南亚移民;（3）高分辨率的Y-SNPs面板对于准确描述父系起源和建立完整和精炼的种族群体遗传结构至关重要。
Yi is the seventh-largest ethnic group in China and features mountainous regional characteristics. The Liangshan Yi Autonomous Prefecture is the largest Yi agglomeration with isolated geographical conditions, profoundly impeding genetic communication. Here, we investigated 427 unrelated males of Liangshan from 193 Y-chromosome single nucleotide polymorphisms (Y-SNPs) and 27 Y-chromosome short tandem repeats (Y-STRs) to reveal the genetic structure and paternal phylogeny of the group. The haplogroup diversity reached 0.9169 with 46 different subhaplogroups by 193 Y-SNPs, and the haplotype diversity reached 0.9999 by 27 Y-STR loci. Multidimensional scaling (MDS), N-J tree, and Network were constructed to decipher and visualize the genetic relations between Yi and worldwide groups. Our results revealed: (1) the Network by Y-STRs and Y-SNPs showed the haplogroup D1a1a-M15 in the Liangshan Yi population was a ramification of Tibetan groups' expansion from west to east on the plateau; (2) the haplogroup distribution and the mismatch mutation analysis indicated the haplogroup O2a2b1a1a1a4a2-Z25929 of Liangshan Yi derived from manifold Southeast Asian immigrants; (3) a high-resolution Y-SNPs panel is vital to depict accurate paternal derivations and build an integrated and refining genetic structure of ethnic groups.