AVERAGED MULTIPLE UNIT-ACTIVITY AS AN ESTIMATE OF PHASIC CHANGES IN LOCAL NEURONAL-ACTIVITY - EFFECTS OF VOLUME-CONDUCTED POTENTIALS
AVERAGED MULTIPLE UNIT-ACTIVITY AS AN ESTIMATE OF PHASIC CHANGES IN LOCAL NEURONAL-ACTIVITY - EFFECTS OF VOLUME-CONDUCTED POTENTIALS
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DOI：
10.1016/0165-0270(80)90061-8
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发表时间：
1980-01-01
影响因子：
3
通讯作者：
VAUGHAN, HG
中科院分区：
文献类型：
--
作者：
LEGATT, AD;AREZZO, J;VAUGHAN, HG
描述了一种用于导出数字平均多单位活动（MUA）的技术。使用信号平均而不是模拟积分提高了时间分辨率，并提供了瞬时MUA水平的更清晰的画面。MUA记录已被用于识别在产生事件相关电位中活跃的区域，部分基于半微电极看到动作电位的有限体积。平均MUA波形可能受到传导至电极部位的时间锁定活动体积的影响。这种影响的大小的理论分析，沿着实验数据支持其假设和预测。最重要的因素不是体积传导电位的绝对大小，而是它们相对于局部产生的MUA的大小。当使用全波整流时，体积传导活动（占MUA水平的相当大的一部分）不会显著影响平均MUA波形。不应使用半波整流，因为它会导致小远场电位产生更大的影响。
A technique for the derivation of digitally-averaged multiple unit activity (MUA) is described. The use of signal averaging instead of analog integration improves the temporal resolution and provides a clearer picture of the instantaneous MUA level. MUA recordings have been used in the identification of regions active in the generation of event-related potentials, based in part on the limited volume within which a semi-microelectrode sees action potentials. Averaged MUA waveforms may be affected by time-locked activity volume-conducted to the electrode site. A theoretical analysis of the magnitude of this effect is presented, along with experimental data in support of its assumptions and predictions. The most important factor is not the absolute size of the volume-conducted potentials, but their magnitude relative to that of the locally-generated MUA. When full-wave rectification is used, volume-conducted activity which is a considerable fraction of the MUA level will not significantly affect the averaged MUA waveform. Half-wave rectification should not be used, as it leads to a much larger effect from small far-field potentials.