Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin
Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin
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DOI：
10.1002/path.1947
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发表时间：
2006-05-01
影响因子：
7.3
通讯作者：
Ochiai, A
中科院分区：
文献类型：
--
作者：
Tsuta, K;Ishii, G;Ochiai, A
最新的世界卫生组织（WHO）分类将腺癌主要分为腺癌混合亚型、腺泡腺癌、乳头状腺癌、细支气管肺泡癌和具有粘蛋白产生的实体腺癌，并且其提到几种变体，包括胎儿腺癌、粘液性（“胶体”）腺癌、粘液性囊腺癌、印戒腺癌和透明细胞腺癌。通常，肺的产生粘蛋白的腺癌包括印戒细胞癌（SRCC）、产生粘蛋白的实体腺癌（SA）和粘液性细支气管肺泡癌（m-BAC）、粘液性（“胶体”）腺癌和/或粘液性囊腺癌和粘液表皮样癌。由于SRCC、SA和m-BAC表现出不同的临床特征，因此重要的是识别其免疫组化特征的差异，以更好地了解其组织发生。在这项研究中，我们分析了SRCC，SA，m-BAC，正常肺，和前肠相关的分泌组织的免疫组织化学差异，使用组织芯片。SRCC和SA中MUC 1、CK 7和TTF 1的表达率分别为97.4%和100%、81.1%和100%。它们还显示MUC 5AC（分别为25.5%和21.1%）和MUC 6（分别为18.3%和10.5%）的低表达，而m-BAC显示MUC 5AC（97.5%）、MUC 6（75.0%）和CK 7（94.7%）的高表达，但MUC 1（57.5%）和TTF-1（27.5%）的低表达。分级聚类分析显示SRCC和SA与肺泡衬里细胞属于同一类，而m-BAC与胃小凹细胞和支气管杯状细胞聚在另一个分支上。这些免疫组化结果支持我们以前的肺SRCC的临床病理学分析的结果，表明SRCC发生在肺的外周部分，而不是在支气管腺体轴承部分的解剖。版权所有（c）2006大不列颠和爱尔兰病理学会。由John Wiley & Sons有限公司出版
The latest World Health Organization (WHO) classification divides adenocarcinoma mainly into adenocarcinoma mixed subtypes, acinar adenocarcinoma, papillary adenocarcinoma, bronchioloalveolar carcinoma, and solid adenocarcinoma with mucin production, and it mentions several variants, including fetal adenocarcinoma, mucinous ("colloid") adenocarcinoma, mucinous cystadenocarcinoma, signet-ring adenocarcinorna, and clear cell adenocarcinoma. In general, the mucin-producing adenocarcinoma of the lung comprises signet-ring cell carcinoma (SRCC), solid adenocarcinorna with mucin production (SA), and mucinous bronchioloalveolar carcinoma (m-BAC), mucinous ("colloid") adenocarcinomas and/or mucinous cystadenocarcinoma, and mucoepidermoid carcinoma. As SRCC, SA, and m-BAC exhibit distinct clinical features, it is important to identify differences in their immunohistochemical characteristics to better understand their histogenesis. In this study we analysed SRCC, SA, m-BAC, normal lung, and foregut-related secretory tissue for immunohistochemical differences using tissue microarrays. SRCC and SA showed high expression of MUC1 (97.4% and 100%, respectively), cytokeratin (CK) 7 (both 100%), and thyroid transcription factor-1 (TTF-1) (81.1% and 100%, respectively). They also showed low expression of MUC5AC (25.5% and 21.1%, respectively) and MUC6 (18.3% and 10.5%, respectively), whereas m-BAC showed high expression of MUC5AC (97.5%), MUC6 (75.0%), and CK7 (94.7%), but low expression of MUC1 (57.5%), and TTF-1 (27.5%). Hierarchical clustering showed that the immunophenotypes of SRCC and SA belong to the same category as alveolar lining cells, whereas m-BAC clustered onto another branch with gastric foveolar cells and bronchial goblet cells. These immunohistochemical findings support the results of our previous clinicopathological analysis of SRCC of the lung showing that SRCC occurs anatomically in the peripheral portion of the lung rather than in the bronchial gland-bearing portion. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.