Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee.
Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee.
复制标题
载脂蛋白 A-I、B 和 C-III 与切诺基青年的肥胖。
DOI：
10.1155/2017/8236325
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发表时间：
2017
影响因子：
5.3
通讯作者：
Lee,Elisa
中科院分区：
文献类型：
--
作者：
Wang,Wenyu;Blackett,Piers;Khan,Sohail;Lee,Elisa
Since young adult Cherokee are at increased risk for both diabetes and cardiovascular disease, we assessed association of apolipoproteins (A‐I, B, and C‐III in non‐HDL and HDL) with obesity and related risk factors. Obese participants (BMI ≥ 30) aged 20–40 years (n= 476) were studied. Metabolically healthy obese (MHO) individuals were defined as not having any of four components of the ATP‐III metabolic syndrome after exclusion of waist circumference, and obese participants not being MHO were defined as metabolically abnormal obese (MAO). Associations were evaluated by correlation and regression modeling. Obesity measures, blood pressure, insulin resistance, lipids, and apolipoproteins were significantly different between groups except for total cholesterol, LDL‐C, and HDL‐apoC‐III. Apolipoproteins were not correlated with obesity measures with the exception of apoA‐I with waist and the waist : height ratio. In a logistic regression model apoA‐I and the apoB : apoA‐I ratio were significantly selected for identifying those being MHO, and the result (C‐statistic = 0.902) indicated that apoA‐I and the apoB : apoA‐I ratio can be used to identify a subgroup of obese individuals with a significantly less atherogenic lipid and apolipoprotein profile, particularly in obese Cherokee men in whom MHO is more likely.
