Pathological ventricular remodeling: mechanisms: part 1 of 2.
Pathological ventricular remodeling: mechanisms: part 1 of 2.
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DOI：
10.1161/circulationaha.113.001878
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发表时间：
2013-07-23
期刊：
影响因子：
37.8
通讯作者：
Hill JA
中科院分区：
文献类型：
--
作者：
Burchfield JS;Xie M;Hill JA
尽管目前的治疗方法降低了心力衰竭的发病率和死亡率，但再住院率仍然很高，对个人、社会和经济产生了重大影响。因此，迫切需要新的治疗进展和新型医疗器械。疾病相关的左心室重构是一个复杂的过程，涉及心肌细胞生长和死亡、血管稀疏、纤维化、炎症和电生理重构。由于这些事件是高度相互关联的，因此靶向单个分子或过程可能是不够的。本文就病理性心室重构的分子和细胞机制作一综述。
Despite declines in heart failure morbidity and mortality with current therapies, re-hospitalization rates remain distressingly high, impacting substantially on individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. As these events are highly inter-related, targeting one single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.