Comparative hemodynamic effects of placebo and oral isosorbide dinitrate in patients with significant coronary artery disease.
Comparative hemodynamic effects of placebo and oral isosorbide dinitrate in patients with significant coronary artery disease.
复制标题
比较安慰剂和口服硝酸异山梨酯对患有严重冠状动脉疾病的患者的血流动力学影响。
DOI：
10.1016/0002-8703(75)90258-6
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发表时间：
1975
影响因子：
4.8
通讯作者：
A. Brest
中科院分区：
文献类型：
--
作者：
H. Kasparian;L. Wiener;P. Duca;R. Gottlieb;A. Brest
比较安慰剂和10 mg的血流动力学效应。研究了口服硝酸异山梨酯在经血管造影证实的严重冠状动脉疾病（管腔狭窄≥ 75%）患者中的作用。硝酸异山梨酯或安慰剂分别给予8名和10名患者，以双盲的方式。在给药前和给药后60分钟评价静息和仰卧腿运动期间的心脏性能。在静息状态下，与安慰剂相比，硝酸异山梨酯显著降低了左心室（收缩压和舒张压）、平均肺动脉压和平均主动脉压、心脏指数、心搏指数、左心室作功指数、心搏作功指数和平均收缩期射血率。硝酸异山梨酯还显著降低运动时左心室（收缩压和舒张压）和平均肺动脉压。这项研究表明，10毫克。口服硝酸异山梨酯60分钟后对缺血性左心室功能障碍有显著影响。
Comparative hemodynamic effects of placebo and 10 mg. of oral isosorbide dinitrate were studied in patients with significant coronary artery disease (≥ 75 per cent lumen narrowing) proved angiographically. Isosorbide dinitrate or placebo was given to eight and 10 patients, respectively, in a double-blind fashion. Cardiac performance at rest and during supine leg exercise was evaluated before and 60 minutes after drug administration. In the resting state, isosorbide dinitrate compared to placebo significantly reduced the left ventricular (systolic and diastolic), mean pulmonary artery and mean aortic pressures, cardiac index, stroke index, left ventricular work index, stroke work index, and mean systolic ejection rate. Isosorbide dinitrate also significantly reduced left ventricular (systolic and diastolic) and mean pulmonary artery pressures during exercise. This study indicates that 10 mg. of isosorbide dinitrate has a significant influence on ischemic left ventricular dysfunction 60 minutes after its oral administration.