ASTHMA, INHALED OXIDANTS, AND DIETARY ANTIOXIDANTS
ASTHMA, INHALED OXIDANTS, AND DIETARY ANTIOXIDANTS
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DOI：
10.1093/ajcn/61.3.625s
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发表时间：
1995-03-01
影响因子：
7.1
通讯作者：
HATCH, GE
中科院分区：
文献类型：
--
作者：
HATCH, GE
探讨了膳食抗氧化剂，尤其是维生素C对哮喘发病率增加的可能影响。普通人群中维生素C的摄入量似乎与哮喘相关，这表明低维生素C饮食是哮喘的风险因素。流行病学研究表明，吸烟者子女接触氧化剂、呼吸道感染和哮喘之间存在关联。成人持续哮喘的症状似乎因暴露于环境氧化剂而增加，而因补充维生素C而减少。有证据表明，过度活跃的炎症细胞内源性产生的氧化剂导致了持续的哮喘。维生素C是存在于肺部呼吸道表面液体中的主要抗氧化剂物质，在保护内源性和外源性氧化剂方面可能具有重要作用。氮氧化物是氧化剂的典范，它可能来自内源性和环境来源，受到维生素C的保护，这可能在哮喘的原因和传播中起重要作用。
The possible influence of dietary antioxidants, especially vitamin C, on the increasing prevalence of asthma is explored. Vitamin C intake in the general population appears to correlate with asthma, suggesting that a diet low in vitamin C is a risk factor for asthma. Epidemiological studies show associations among oxidant exposure, respiratory infections, and asthma in children of smokers. Symptoms of ongoing asthma in adults appear to be increased by exposure to environmental oxidants and decreased by vitamin C supplementation. There is evidence that oxidants produced endogenously by overactive inflammatory cells contribute to ongoing asthma. Vitamin C is the major antioxidant substance present in the airway surface liquid of the lung, where it could be important in protecting against both endogenous and exogenous oxidants. Nitrogen oxides are exemplary of oxidants that could arise from both endogenous and environmental sources, which are protected against by vitamin C, and that may be important in causation and propagation of asthma.