Electrospinning collagen and elastin: Preliminary vascular tissue engineering
Electrospinning collagen and elastin: Preliminary vascular tissue engineering
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DOI：
10.2741/1313
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Bowlin, GL
中科院分区：
文献类型：
--
作者：
Boland, ED;Matthews, JA;Bowlin, GL
在充分实现血管组织工程的真正益处和经济影响之前，必须克服重大挑战。为此，我们开创了从天然聚合物胶原蛋白和弹性蛋白中静电纺丝微纤维和纳米纤维支架，并将其应用于仿生血管组织工程构建的开发。血管壁的组成和结构是高度复杂的，并赋予独特的生物力学性质，这对开发能够承受血流的高压和脉动环境的活组织工程化血管替代物提出了挑战。本文提出的新型支架用于开发可行的血管假体的潜力满足了这些严格的要求，因为它可以复制血管壁的复杂结构。这种复制潜力为血管替代物的后续体外开发创造了“理想”环境。本文提出的研究提供了初步的数据，朝着发展的电纺胶原蛋白和弹性蛋白组织工程支架的三层血管结构的发展。
Significant challenges must be overcome before the true benefit and economic impact of vascular tissue engineering can be fully realized. Toward that end, we have pioneered the electrospinning of micro- and nano-fibrous scaffoldings from the natural polymers collagen and elastin and applied these to development of biomimicking vascular tissue engineered constructs. The vascular wall composition and structure is highly intricate and imparts unique biomechanical properties that challenge the development of a living tissue engineered vascular replacement that can withstand the high pressure and pulsatile environment of the bloodstream. The potential of the novel scaffold presented here for the development of a viable vascular prosthetic meets these stringent requirements in that it can replicate the complex architecture of the blood vessel wall. This replication potential creates an "ideal" environment for subsequent in vitro development of a vascular replacement. The research presented herein provides preliminary data toward the development of electrospun collagen and elastin tissue engineering scaffolds for the development of a three layer vascular construct.