Do food and stress biomarkers work for wastewater-based epidemiology? A critical evaluation
Do food and stress biomarkers work for wastewater-based epidemiology? A critical evaluation
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DOI：
10.1016/j.scitotenv.2020.139654
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发表时间：
2020-09-20
影响因子：
9.8
通讯作者：
Mueller, J. F.
中科院分区：
文献类型：
--
作者：
Choi, P. M.;Bowes, D. A.;Mueller, J. F.
饮食特征和氧化应激与个体的健康密切相关。近年来，人们提出将食物和氧化应激的各种尿液生物标志物用于基于废水的流行病学（WBE），以客观地监测废水流域中个体所消耗的食物和所经历的氧化应激。然而，尚不清楚此类生物标志物是否适合基于废水的流行病学。本研究提出了一套 30 种尿液食物和氧化应激生物标志物，并评估了它们在 WBE 研究中的适用性。其中包括 22 种以前未考虑用于 WBE 研究的生物标志物。从澳大利亚 9 个流域的 57 个废水流入样品中测量了每日人均生物标志物负荷。使用实验室规模的下水道反应器评估生物标志物的稳定性。尽管在下水道反应器中易于降解，但维生素 B2、维生素 B3 和纤维以及柑橘成分的人均消耗量生物标志物与报道的文献值一致。红肉、鱼、水果、其他维生素的消费生物标志物和压力生物标志物的人均值与文献研究结果不一致，和/或在下水道反应器中迅速降解，表明它们不适合用作传统定量意义上的 WBE 生物标志物。这项研究旨在传达食物和氧化应激生物标志物对未来 WBE 研究的适用性。 (c) 2020 Elsevier B.V. 保留所有权利。
Dietary characteristics and oxidative stress are closely linked to the wellbeing of individuals. In recent years, various urinary biomarkers of food and oxidative stress have been proposed for use in wastewater-based epidemiology (WBE), in efforts to objectively monitor the food consumed and the oxidative stress experienced by individuals in a wastewater catchment. However, it is not clear whether such biomarkers are suitable for wastewater-based epidemiology. This study presents a suite of 30 urinary food and oxidative stress biomarkers and evaluates their applicability for WBE studies. This includes 22 biomarkers which were not previously considered for WBE studies. Daily per capita loads of biomarkers were measured from 57 wastewater influent samples from nine Australian catchments. Stability of biomarkers were assessed using laboratory scale sewer reactors. Biomarkers of consumption of vitamin B2, vitamin B3 and fibre, as well as a component of citrus had per capita loads in line with reported literature values despite susceptibility of degradation in sewer reactors. Consumption biomarkers of red meat, fish, fruit, other vitamins and biomarkers of stress had per capita values inconsistent with literature findings, and/or degraded rapidly in sewer reactors, indicating that they are unsuitable for use as WBE biomarkers in the traditional quantitative sense. This study serves to communicate the suitability of food and oxidative stress biomarkers for future WBE research. (c) 2020 Elsevier B.V. All rights reserved.