Impact of Microbial Metabolites on Microbiota-Gut-Brain Axis in Inflammatory Bowel Disease.
Impact of Microbial Metabolites on Microbiota-Gut-Brain Axis in Inflammatory Bowel Disease.
复制标题
微生物代谢产物对炎症性肠病中微生物群-肠道-脑轴的影响
DOI：
10.3390/ijms22041623
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发表时间：
2021-02-05
影响因子：
5.6
通讯作者：
Baj A
中科院分区：
文献类型：
--
作者：
Banfi D;Moro E;Bosi A;Bistoletti M;Cerantola S;Crema F;Maggi F;Giron MC;Giaroni C;Baj A
胃肠道与大脑之间存在复杂的双向通信系统，最初被称为“肠-脑轴”，鉴于肠道微生物群在维持局部和全身内稳态中的关键作用，该系统又被重新命名为“微生物群-肠-脑轴”。这一系统在炎症性肠病（IBD）的发病机制中起着基础性作用。源自宿主神经、免疫和内分泌系统的信号与源自微生物群的信号相互整合，这可能影响局部炎症损伤的发展，还会对更远处的大脑区域产生影响，这正是IBD患者心理生理易感性的基础。情绪障碍和对应激反应增强常与IBD相关，可能影响疾病的复发和严重程度，因此除了常规的抗炎治疗外，还需要适当的治疗方法。
这篇综述着重介绍了最新证据，这些证据表明微生物群-肠-脑双向通信轴的改变可能与IBD的发病机制有关，并促使局部和中枢神经系统症状的发展。我们还将讨论主要的微生物衍生代谢产物（也被定义为“后生元”），如胆汁酸、短链脂肪酸和色氨酸代谢产物，在IBD相关的肠道和大脑功能障碍发展过程中的作用。最后一部分将对主要临床证据进行批判性评估，这些证据指向基于微生物群的治疗方法，用于治疗IBD相关的胃肠道和神经精神症状 。
The complex bidirectional communication system existing between the gastrointestinal tract and the brain initially termed the “gut–brain axis” and renamed the “microbiota–gut–brain axis”, considering the pivotal role of gut microbiota in sustaining local and systemic homeostasis, has a fundamental role in the pathogenesis of Inflammatory Bowel Disease (IBD). The integration of signals deriving from the host neuronal, immune, and endocrine systems with signals deriving from the microbiota may influence the development of the local inflammatory injury and impacts also more distal brain regions, underlying the psychophysiological vulnerability of IBD patients. Mood disorders and increased response to stress are frequently associated with IBD and may affect the disease recurrence and severity, thus requiring an appropriate therapeutic approach in addition to conventional anti-inflammatory treatments. This review highlights the more recent evidence suggesting that alterations of the microbiota–gut–brain bidirectional communication axis may concur to IBD pathogenesis and sustain the development of both local and CNS symptoms. The participation of the main microbial-derived metabolites, also defined as “postbiotics”, such as bile acids, short-chain fatty acids, and tryptophan metabolites in the development of IBD-associated gut and brain dysfunction will be discussed. The last section covers a critical evaluation of the main clinical evidence pointing to the microbiome-based therapeutic approaches for the treatment of IBD-related gastrointestinal and neuropsychiatric symptoms.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
9.8
作者：
Angelberger, Sieglinde;Reinisch, Walter;Erry, David B.
通讯作者：
Erry, David B.
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
影响因子：
4.4
作者：
Aoki, Reiji;Aoki-Yoshida, Ayako;Takayama, Yoshiharu
通讯作者：
Takayama, Yoshiharu
影响因子：
4.4
作者：
Biagioli, Michele;Carino, Adriana;Fiorucci, Stefano
通讯作者：
Fiorucci, Stefano