Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers
Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers
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DOI：
10.1006/bbrc.1997.6942
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发表时间：
1997-07-18
影响因子：
3.1
通讯作者：
Yuasa, Y
中科院分区：
文献类型：
--
作者：
Akiyama, Y;Tsubouchi, N;Yuasa, Y
hMSH3 is one of the human DNA mismatch repair genes but has not yet been reported to be associated with hereditary nonpolyposis colorectal cancer. Recently, somatic mutation at a polyadenine tract, i.e., (A)(8), in hMSH3 was reported in cancers with microsatellite instability (MI). To clarify the tumorigenetic role of hMSH3, we screened for somatic mutations at the hMSH3 (A)(8) repeat in 29 tumors from 23 hereditary nonpolyposis colorectal cancer patients. One or two A deletions in the (A)(8) repeat were found in 11 (57.9%) of the 19 MI-positive tumors but not in 10 MI-negative ones, indicating secondary mutations after germline mutations of other mismatch repair genes Moreover, the MI frequency of three or more nucleotide repeats was higher in hMSH3 (A)(8)-mutated tumor cells than in nonmutated ones (p
