Eating rate is a heritable phenotype related to weight in children
Eating rate is a heritable phenotype related to weight in children
复制标题
DOI：
10.3945/ajcn.2008.26175
复制
发表时间：
2008-12-01
影响因子：
7.1
通讯作者：
Wardle, Jane
中科院分区：
文献类型：
--
作者：
Llewellyn, Clare H.;van Jaarsveld, Cornelia H. M.;Wardle, Jane
背景：人们对与肥胖相关的行为表型的遗传性越来越感兴趣。一个潜在的候选者是进食速度，尽管现有的与体重相关的证据是混合的。 目的：我们的目的是评估 10-12 岁儿童样本的进食速度，以检验较高的进食速度与肥胖程度相关以及进食速度是一种遗传特征的假设。 设计：使用 254 名双胞胎儿童在家吃标准餐的视频数据来记录进食速度（一口/分钟）以及 4 个季度的进食速度变化。餐。肥胖程度以相对于英国 1990 年标准的体重指数 SD 分数为索引；在一些分析中，儿童被分为超重或肥胖组以及两个正常体重亚组（正常体重较低或正常体重较高），以比较正常范围内以及临床组和非临床组之间的进食率。所有分析都控制成对的聚类。使用标准双胞胎方法对进食率的遗传力进行建模。结果：3 个体重组的进食率存在显着的线性相关性 (P = 0.010)，回归分析显示，体重指数 SD 评分每增加 1 个单位，进食率就会增加 0.18 口/分钟 (P = 0.005)。进食率遗传力较高（0.62；95% CI：0.45，0.74）。体重组与进餐期间进食速度的变化（即减慢）之间没有关联。结论：更快的进食似乎是与较高体重相关的可遗传行为表型。美国临床营养杂志 2008； 88：1560-6。
Background: There is growing interest in the heritability of behavioral phenotypes related to adiposity. One potential candidate is the speed of eating, although existing evidence for an association with weight is mixed.Objective: We aimed to assess the speed of eating in a sample of 10-12-y-old children to test the hypotheses that higher eating rate is related to greater adiposity and that eating rate is a heritable characteristic.Design: Video data of 254 twin children eating a standard meal at home were used to record eating rate (bites/min) and changes in eating rate across the 4 quarters of the meal. Adiposity was indexed with body mass index SD scores relative to British 1990 norms; for some analyses, children were categorized into groups of overweight or obese and into 2 subgroups of normal-weight (lower normal-weight or higher normal-weight) for comparison of the eating rate within the normal range as well as between clinical and nonclinical groups. All analyses controlled for clustering in twin pairs. Heritability of eating rate was modeled by using standard twin methods.Results: There was a significant linear association across the 3 weight groups for eating rate (P = 0.010), and regression analyses showed that eating rate increased by 0.18 bites/min for each 1-unit increase in body mass index SD score (P = 0.005). The heritability of eating rate was high (0.62; 95% CI: 0.45, 0.74). There was no association between weight group and a change (ie, deceleration) in eating rate over the mealtime.Conclusion: Faster eating appears to be a heritable behavioral phenotype related to higher weight. Am J Clin Nutr 2008; 88: 1560-6.