Social Facilitation of Long-Lasting Memory Retrieval in Drosophila
Social Facilitation of Long-Lasting Memory Retrieval in Drosophila
复制标题
DOI：
10.1016/j.cub.2009.08.017
复制
发表时间：
2009-10-13
期刊：
影响因子：
9.2
通讯作者：
Preat, Thomas
中科院分区：
文献类型：
--
作者：
Chabaud, Marie-Ange;Isabel, Guillaume;Preat, Thomas
最近的研究表明，社会互动可以对果蝇的行为[1-8]和角质信息素模式[8-10]产生深远的影响。嗅觉记忆的表现大多是在群体中研究的，之前的研究报告称，在短期记忆提取过程中，成群的果蝇不会相互作用，其行为方式与单独的果蝇相同[11-13]。然而，社会效应对果蝇长效联想记忆的两种已知形式--麻醉抵抗记忆(ARM)和长时记忆(LTM)--的影响尚未见报道。我们在这里表明，ARM是由个体苍蝇展示的，但也是社会促进的；接受ARM训练的苍蝇在一个群体内相互作用，以提高它们的条件反射表现。相比之下，测试显示个体苍蝇的LTM有所改善，而不是在一组苍蝇中。我们发现，ARM在团体测试中的社会促进作用与训练的社会背景无关，也不涉及非特异性聚集。此外，我们还证明了社会互动促进了ARM的提取。我们还表明，这种促进作用所需的社会互动是由训练有素的苍蝇特定产生的：当为ARM训练的单个苍蝇与一群幼稚的苍蝇混合时，它们表现出较差的检索能力，而与为ARM或LTM训练的群体混合则提高了性能。
Recent studies demonstrate that social interactions can have a profound influence on Drosophila melanogaster behavior [1-8] and cuticular pheromone patterns [8-10]. Olfactory memory performance has mostly been investigated in groups, and previous studies have reported that grouped flies do not interact with each other and behave in the same way as individual flies during short-term memory retrieval [11-13]. However, the influence of social effects on the two known forms of Drosophila long-lasting associative memory, anesthesia-resistant memory (ARM) and long-term memory (LTM), has never been reported. We show here that ARM is displayed by individual flies but is socially facilitated; flies trained for ARM interact within a group to improve their conditioned performance. In contrast, testing shows LTM improvement in individual flies rather than in a group. We show that the social facilitation of ARM during group testing is independent of the social context of training and does not involve nonspecific aggregation. Furthermore, we demonstrate that social interactions facilitate ARM retrieval. We also show that social interactions necessary for this facilitation are specifically generated by trained flies: when single flies trained for ARM are mixed with groups of naive flies, they display poor retrieval, whereas mixing with groups trained either for ARM or LTM enhances performance.